ArticleThe Journal of cell biology1999
Mutations in the alpha-tubulin 67C gene specifically impair achiasmate segregation in Drosophila melanogaster.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- A deficiency screen of the 3rd chromosome for dominant modifiers of the Drosophila ER integral membrane protein, Jagunal.G3 (Bethesda, Md.) · 2023Article
- α-Tubulin Regulates the Fate of Germline Stem Cells in Drosophila Testis.Scientific reports · 2021Article
- Female Meiosis: Synapsis, Recombination, and Segregation inGenetics · 2018Review
- Meiosis: an overview of key differences from mitosis.Cold Spring Harbor perspectives in biology · 2015Review
- Article
- Fine scale analysis of gene expression in Drosophila melanogaster gonads reveals Programmed cell death 4 promotes the differentiation of female germline stem cells.BMC developmental biology · 2012Article
- Article
- Heterochromatic threads connect oscillating chromosomes during prometaphase I in Drosophila oocytes.PLoS genetics · 2009Article
- Article
- Article
- The HhH2/NDD domain of the Drosophila Nod chromokinesin-like protein is required for binding to chromosomes in the oocyte nucleus.Genetics · 2005Article
- All paired up with no place to go: pairing, synapsis, and DSB formation in a balancer heterozygote.PLoS genetics · 2005Article
- Drosophila Nod protein binds preferentially to the plus ends of microtubules and promotes microtubule polymerization in vitro.Molecular biology of the cell · 2005Article
- The Kavar(D) dominant female-sterile mutations of Drosophila reveal a role for the maternally provided alpha-tubulin4 isoform in cleavage spindle maintenance and elongation.Molecular genetics and genomics : MGG · 2005Article
- Article
- Pairing, connecting, exchanging, pausing and pulling chromosomes.EMBO reports · 2005Article
- Identification of hypomorphic and null alleles of swallow via molecular and phenotypic analyses.Development genes and evolution · 2004Article
- Meiosis-specific failure of cell cycle progression in fission yeast by mutation of a conserved beta-tubulin residue.Molecular biology of the cell · 2004Article
- A survey of ovary-, testis-, and soma-biased gene expression in Drosophila melanogaster adults.Genome biology · 2004Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila melanogaster oocytes heterozygous for mutations in the alpha-tubulin 67C gene (alphatub67C) display defects in centromere positioning during prometaphase of meiosis I. The centromeres do not migrate to the poleward edges of the chromatin mass, and the chromatin fails to stretch during spindle lengthening. These results suggest that the poleward forces acting at the kinetochore are compromised in the alphatub67C mutants. Genetic studies demonstrate that these mutations also strongly and specifically decrease the fidelity of achiasmate chromosome segregation. Proper centromere orientation, chromatin elongation, and faithful segregation can all be restored by a decrease in the amount of the Nod chromokinesin. These results suggest that the accurate segregation of achiasmate chromosomes requires the proper balancing of forces acting on the chromosomes during prometaphase.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.