ArticleGut2000
Changes in gastric acid secretion assayed by endoscopic gastrin test before and after Helicobacter pylori eradication.
Article in Gut, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 122 citations in OpenAlex.
- Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial.Journal of gastroenterology · 2011Trial
- Validation of a new endoscopic technique to assess acid output in Zollinger-Ellison syndrome.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2006Trial
- Randomised controlled trial of effects of Helicobacter pylori infection and its eradication on heartburn and gastro-oesophageal reflux: Bristol helicobacter project.BMJ (Clinical research ed.) · 2004Trial
- Measurement of postprandial changes in urine acid output to detect changes of gastric acid secretion after proton pump inhibitors in children.Digestive diseases and sciences · 2002Trial
- A steadily increasing trend in the incidence of esophageal adenocarcinoma in Akita Prefecture, Japan, through 2024.Journal of gastroenterology · 2026Article
- Characteristics and background mucosa status of early gastric cancer after Helicobacter pylori eradication: A narrative review.Medicine · 2022Review
- Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term.BMC gastroenterology · 2021Article
- How did the ancient bacterium,JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Association of residual gastric acid secretion with persistent symptoms in gastroesophageal reflux disease patients receiving standard-dose proton pump inhibitor therapy.Esophagus : official journal of the Japan Esophageal Society · 2021Article
- Prevalence of Barrett's Epithelium Shown by Endoscopic Observations with Linked Color Imaging in Subjects with Different H. pylori Infection Statuses.Internal medicine (Tokyo, Japan) · 2021Article
- The relationship betweenTherapeutic advances in gastroenterology · 2021Article
- Is the new potent acid-inhibitory drug vonoprazan effective for healing idiopathic peptic ulcers? A multicenter observational study in Akita Prefecture, Japan.Journal of gastroenterology · 2019Observational
- Relationship of Helicobacter pylori Infection with Gastric Black Spots Shown by Endoscopy.Internal medicine (Tokyo, Japan) · 2019Article
- Prevalence of Multiple White and Flat Elevated Lesions in Individuals Undergoing a Medical Checkup.Internal medicine (Tokyo, Japan) · 2018Article
- Usefulness of Endoscopic Imaging to Visualize Regional Alterations in Acid Secretion of Noncancerous Gastric Mucosa afterJournal of gastric cancer · 2016Article
- Does Helicobacter pylori Exacerbate Gastric Mucosal Injury in Users of Nonsteroidal Anti-Inflammatory Drugs? A Multicenter, Retrospective, Case-Control Study.Gut and liver · 2016Article
- Review
- Time series analysis of gastric acid secretion over a 20-year period in normal Japanese men.Journal of gastroenterology · 2015Article
- Reflux esophagitis triggered after Helicobacter pylori eradication: a noteworthy demerit of eradication therapy among the Japanese?Frontiers in microbiology · 2015Article
- Brain-gut axis in the pathogenesis of Helicobacter pylori infection.World journal of gastroenterology · 2014Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt remains controversial whether or not Helicobacter pylori infection causes altered gastric acid secretion. A novel test for evaluating gastric acid secretion (endoscopic gastrin test; EGT) has recently been developed.
aimTo investigate by EGT the effects of H pylori eradication on the state of gastric acid secretion in patients with peptic ulcer.
methodsTwenty six patients with duodenal ulcer and 33 with gastric ulcer, for all of whom H pylori infection had been documented, were studied by EGT, histological examination of gastric mucosa, and measurement of plasma gastrin levels before and one and seven months after H pylori eradication.
resultsIn patients with duodenal ulcer, the mean EGT value before H pylori eradication was higher than that in H pylori negative controls, but it had decreased significantly seven months after the treatment. In contrast, the mean EGT value of patients with gastric ulcer before H pylori eradication was lower than that in H pylori negative controls, but it had increased one month after the treatment; this was followed by a slight decrease at seven months. In both groups, mean EGT values seven months after the treatment were not significantly different from the mean control value.
conclusionsThe reduced acid secretion in gastric ulcer patients and gastric acid hypersecretion in duodenal ulcer patients were both normalised after the clearance of H pylori.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.