ArticleOncogene1999
SIAH-1 inhibits cell growth by altering the mitotic process.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- The E3 Ubiquitin Ligase Siah-1 Suppresses Avian Reovirus Infection by Targeting p10 for Degradation.Journal of virology · 2018Article
- SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status.Cell cycle (Georgetown, Tex.) · 2015Article
- E3 ubiquitin ligase Siah-1 downregulates synaptophysin expression under high glucose and hypoxia.American journal of translational research · 2015Article
- Structure-based design of covalent Siah inhibitors.Chemistry & biology · 2013Article
- Expression and clinical significance of SIAH in laryngeal squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2013Article
- Distinct expression patterns of the E3 ligase SIAH-1 and its partner Kid/KIF22 in normal tissues and in the breast tumoral processes.Journal of experimental & clinical cancer research : CR · 2010Article
- siah-1 Protein is necessary for high glucose-induced glyceraldehyde-3-phosphate dehydrogenase nuclear accumulation and cell death in Muller cells.The Journal of biological chemistry · 2010Article
- Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases.The Journal of biological chemistry · 2009Article
- Siah-1S, a novel splice variant of Siah-1 (seven in absentia homolog), counteracts Siah-1-mediated downregulation of beta-catenin.Oncogene · 2007Article
- Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?Oncogene · 2004Article
- Siah-1b is a direct transcriptional target of p53: identification of the functional p53 responsive element in the siah-1b promoter.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Article
- Normal p53 function in primary cells deficient for Siah genes.Molecular and cellular biology · 2002Article
- Biological models and genes of tumor reversion: cellular reprogramming through tpt1/TCTP and SIAH-1.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Phyllopod acts as an adaptor protein to link the sina ubiquitin ligase to the substrate protein tramtrack.Molecular and cellular biology · 2002Article
- The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice.Molecular and cellular biology · 2002Article
- Siah-1 binds and regulates the function of Numb.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- A role for Seven in Absentia Homolog (Siah1a) in metabotropic glutamate receptor signaling.BMC neuroscience · 2001Article
- SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis.Oncogene · 2000Article
- The nucleoporin Nup153 affects spindle checkpoint activity due to an association with Mad1.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
SIAH-1, the human homologue of the drosophila seven in absentia gene, is a p53-p21Waf-1 inducible gene. We report that stable transfection with SIAH-1 of the epithelial breast cancer cell line MCF-7 blocks its growth process. The transfectants show a redistribution of SIAH-1 protein within the nucleus, more specifically to the nuclear matrix, associated to dramatic changes in cell morphology and defective mitosis. Multinucleated giant cells (2-12 nuclei in more than 50% cells) were a most striking observation associated with tubulin spindle disorganization and defective cytokinesis. There were also present at high frequency abortive mitotic figures, DNA bridges and persistance of intercellular bridges and midbodies, along with an increased expression of p21Waf-1. These results indicate that the mechanism of growth arrest induced by SIAH-1 in MCF-7 cells involves disorganization of the mitotic program, mainly during nuclei separation and cytokinesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.