ArticleOncogene1999
The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma.International journal of molecular sciences · 2022Article
- Transcription factor POU4F2 promotes colorectal cancer cell migration and invasion through hedgehog-mediated epithelial-mesenchymal transition.Cancer science · 2021Article
- Linking metabolic dysfunction with cardiovascular diseases: Brn-3b/POU4F2 transcription factor in cardiometabolic tissues in health and disease.Cell death & disease · 2021Review
- The POU4F2/Brn-3b transcription factor is required for the hypertrophic response to angiotensin II in the heart.Cell death & disease · 2019Article
- POU4F2/Brn-3b transcription factor is associated with survival and drug resistance in human ovarian cancer cells.Oncotarget · 2018Article
- SpliceRCA:ACS central science · 2018Article
- A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome.Scientific reports · 2017Article
- Somatic Genomics and Clinical Features of Lung Adenocarcinoma: A Retrospective Study.PLoS medicine · 2016Article
- Profound hyperglycemia in knockout mutant mice identifies novel function for POU4F2/Brn-3b in regulating metabolic processes.American journal of physiology. Endocrinology and metabolism · 2016Article
- Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults.Cell death & disease · 2014Article
- Quantitative imaging of single mRNA splice variants in living cells.Nature nanotechnology · 2014Article
- The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival.EMBO molecular medicine · 2013Article
- Hsp-27 induction requires POU4F2/Brn-3b TF in doxorubicin-treated breast cancer cells, whereas phosphorylation alters its cellular localisation following drug treatment.Cell stress & chaperones · 2011Article
- Proliferation-associated POU4F2/Brn-3b transcription factor expression is regulated by oestrogen through ERα and growth factors via MAPK pathway.Breast cancer research : BCR · 2011Article
- Deregulation of the Pit-1 transcription factor in human breast cancer cells promotes tumor growth and metastasis.The Journal of clinical investigation · 2010Article
- Neuronal transcription factor Brn-3a(l) is over expressed in high-grade ovarian carcinomas and tumor cells from ascites of patients with advanced-stage ovarian cancer.Journal of ovarian research · 2010Article
- Verification of genes differentially expressed in neuroblastoma tumours: a study of potential tumour suppressor genes.BMC medical genomics · 2009Article
- Transcription factors: their potential as targets for an individualized therapeutic approach to cancer.Cancer gene therapy · 2009Review
- Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression.Cell stress & chaperones · 2008Article
- Direct inhibition of the DNA-binding activity of POU transcription factors Pit-1 and Brn-3 by selective binding of a phenyl-furan-benzimidazole dication.Nucleic acids research · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The BRCA-1 tumour supressor gene was identified on the basis of mutations which occur in familial breast cancer indicating that its inactivation can cause this disease. Although BRCA-1 does not appear to be mutated in sporadic breast cancer, its expression has been shown to be reduced in tumour material from such cases. We show here that mammary tumours which have reduced levels of BRCA-1 expression show enhanced expression of the Brn-3b POU family transcription factor at both the mRNA and protein levels. This elevated expression of Brn-3b is not found in normal mammary cells, benign tumours or in malignant tumour samples which do not exhibit reduced levels of BRCA-1. In contrast, no correlation was noted between BRCA-1 and expression of the related factor Brn-3a. Moreover, Brn-3b but not Brn-3a can strongly repress the BRCA-1 promoter approximately 20-fold in mammary tumour cells. To our knowledge, this is the first report of a transcription factor which regulates BRCA-1 expression. Thus, Brn-3b may play an important role in regulating expression of BRCA-1 in mammary tumours with enhanced expression of Brn-3b resulting in reduced BRCA-1 expression and thereby being potentially important in tumour development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.