ArticleOncogene1999
Close correlation between beta-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 120 citations in OpenAlex.
- Trial
- Human liver organoids for disease modeling of fibrolamellar carcinoma.Stem cell reports · 2022Article
- Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival.Journal of cancer research and clinical oncology · 2021Article
- Novel Mutations in Pilomatrixoma, CTNNB1 p.s45F, and FGFR2 p.s252L: A Report of Three Cases Diagnosed by Fine-Needle Aspiration Biopsy, with Review of the Literature.Case reports in genetics · 2020Article
- Review
- Development of new preclinical models to advance adrenocortical carcinoma research.Endocrine-related cancer · 2018Article
- Fibrolamellar Carcinoma: Recent Advances and Unresolved Questions on the Molecular Mechanisms.Seminars in liver disease · 2018Review
- Role of Wnt/β-catenin signaling in hepatocellular carcinoma, pathogenesis, and clinical significance.Journal of hepatocellular carcinoma · 2018Review
- Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma.Journal of gastroenterology · 2017Review
- C-terminal-truncated HBV X promotes hepato-oncogenesis through inhibition of tumor-suppressive β-catenin/BAMBI signaling.Experimental & molecular medicine · 2016Article
- Correlation of exon 3 β-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- DNA markers in molecular diagnostics for hepatocellular carcinoma.Expert review of molecular diagnostics · 2014Review
- Expression of RUNX3 and β-catenin in the carcinogenesis of sporadic colorectal tubular adenoma.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Elevated levels of Dickkopf-1 are associated with β-catenin accumulation and poor prognosis in patients with chondrosarcoma.PloS one · 2014Article
- Clinicopathological analysis of hepatocellular adenoma according to new bordeaux classification: report of eight korean cases.Korean journal of pathology · 2013Article
- New insights in hepatocellular carcinoma: from bench to bedside.Annals of translational medicine · 2013Review
- Fibrolamellar carcinoma: 2012 update.Scientifica · 2012Review
- Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype.PloS one · 2012Article
- Therapeutics Based on microRNA: A New Approach for Liver Cancer.Current genomics · 2010Article
- Molecular genetics of hepatocellular neoplasia.American journal of translational research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several lines of evidence indicate that beta-catenin acquires oncogenic activity when its intracellular concentration increases as a result of either mutation in the beta-catenin gene itself or inactivation of the adenomatous polyposis coli (APC) gene. In an attempt to elucidate the molecular mechanisms underlying hepatocellular carcinogenesis, we have studied the frequency of beta-catenin gene alterations in exon 3, a region known to represent a mutation hot spot, and its inappropriate protein expression by immunohistochemistry in 73 hepatocellular carcinomas (HCCs). The results were correlated with different clinical and pathological data, particularly with the presence or not of an associated cirrhosis. Fourteen (19%) HCCs showed beta-catenin gene alterations with missense mutations in nine cases and interstitial deletions in five cases. These genetic alterations were present in both cirrhotic and non-cirrhotic groups. By contrast, we did not find any beta-catenin gene alterations in the nine fibromellar carcinomas we examined. Nuclear accumulation of the protein was observed in 18 of them (25%). Remarkably, these included ten of the 14 tumors harboring somatic mutations in the beta-catenin gene (P < 0.001). Our results indicate that accumulation of beta-catenin resulting from genetic mutations is a frequent event in non-fibrolamellar type hepatocellular carcinoma. The close association between increased beta-catenin protein stability and mutation indicates that immunohistochemistry may be a powerful method for the detection of the mutated protein in future clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.