ArticleOncogene1999
Activation of Hex and mEg5 by retroviral insertion may contribute to mouse B-cell leukemia.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Antitumor Activity of Tetrahydro-β-carboline Derivatives via Inhibition of Kinesin Spindle Protein: Validation by Molecular Docking, Molecular Dynamics, and In Vitro Assays.International journal of molecular sciences · 2025Article
- The Kinesin Eg5 Inhibitor K858 Enhances Radiosensitivity in Esophageal Squamous Cell Carcinoma and Affects the Expression of Epithelial-mesenchymal Transition Related Markers:Anti-cancer agents in medicinal chemistry · 2025Article
- KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia.Journal of cancer research and clinical oncology · 2023Article
- The Haematopoietically-expressed homeobox transcription factor: roles in development, physiology and disease.Frontiers in immunology · 2023Review
- Kinesin family member 11 is a potential therapeutic target and is suppressed by microRNA-30a in breast cancer.Molecular carcinogenesis · 2020Article
- MicroRNA-186-5p represses neuroblastoma cell growth via downregulation ofAmerican journal of translational research · 2019Article
- Cancer drug therapy and stochastic modeling of "nano-motors".International journal of nanomedicine · 2018Article
- High Eg5 expression predicts poor prognosis in breast cancer.Oncotarget · 2017Article
- Overexpression of Eg5 correlates with high grade astrocytic neoplasm.Journal of neuro-oncology · 2016Article
- Hhex is Required at Multiple Stages of Adult Hematopoietic Stem and Progenitor Cell Differentiation.Stem cells (Dayton, Ohio) · 2015Article
- Article
- Review
- Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation.Cell cycle (Georgetown, Tex.) · 2013Article
- The expression of Eg5 predicts a poor outcome for patients with renal cell carcinoma.Medical oncology (Northwood, London, England) · 2013Article
- A mechanism of nucleocytoplasmic trafficking for the homeodomain protein PRH.Molecular and cellular biochemistry · 2009Article
- Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells.Leukemia · 2009Article
- PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate.The Biochemical journal · 2008Review
- Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Fanconi anemia C gene product regulates expression of genes involved in differentiation and inflammation.Oncogene · 2004Article
- Genetic complementation of cytokine signaling identifies central role of kinases in hematopoietic cell proliferation.Oncogene · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
AKXD recombinant inbred mice develop a variety of leukemias and lymphomas due to retrovirally mediated insertional activation of cellular proto-oncogenes. We describe a new retroviral insertion site that is the most frequent genetic alteration in AKXD B-cell leukemias. Multiple genes flank the site of viral insertion, but the expression of just two, Hex and mEg5, is significantly upregulated. Hex is a divergent homeobox gene that is transiently expressed in many hematopoietic lineages, suggesting an involvement in cellular differentiation. mEg5 is a member of the bim-C subfamily of kinesin related proteins that are necessary for spindle formation and stabilization during mitosis. Our data provide the first genetic evidence for the activation of these genes in leukemia, and suggest that unscheduled expression of Hex and mEg5 contributes to the development of B-cell leukemia. In addition, this work highlights the use of genomic approaches for the study of position effect mutations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.