ArticleOncogene1999
Testicular wild-type p53 expression in transgenic mice induces spermiogenesis alterations ranging from differentiation defects to apoptosis.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- A Test of the Adaptive Lag Hypothesis of the Evolution of Cancer Suppression and Lifespan in Dog Breeds.Genes · 2026Article
- Review
- The role of p53 in male infertility.Frontiers in endocrinology · 2024Review
- Reproductive Hormones Imbalance, Germ Cell Apoptosis, Abnormal Sperm Morphophenotypes and Ultrastructural Changes in Testis of African Giant Rats (Cricetomys gambianus) Exposed to Sodium Metavanadate Intoxication.Environmental science and pollution research international · 2022Article
- SIRT1: A Key Player in Male Reproduction.Life (Basel, Switzerland) · 2022Review
- Molecular and Cellular Mechanisms of Apoptosis during Dissociated Spermatogenesis.Frontiers in physiology · 2017Article
- Article
- The Magea gene cluster regulates male germ cell apoptosis without affecting the fertility in mice.Scientific reports · 2016Article
- Knockout of BRD7 results in impaired spermatogenesis and male infertility.Scientific reports · 2016Article
- Modeling the study of DNA damage responses in mice.Methods in molecular biology (Clifton, N.J.) · 2015Review
- The MDM2-p53 pathway: multiple roles in kidney development.Pediatric nephrology (Berlin, Germany) · 2014Review
- Article
- The emerging role of matrix metalloproteases of the ADAM family in male germ cell apoptosis.Spermatogenesis · 2011Article
- P53 expression between 13-27 weeks old human male fetus gonads.Journal of molecular histology · 2007Article
- Article
- The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis.Molecular and cellular biology · 2003Article
- "Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally.The EMBO journal · 2002Article
- Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While p53 is dispensable for development, an excess of p53 has dramatic consequences on the embryogenesis and on the cell differentiation. In an attempt to analyse in vivo the effects of p53 activity, we have generated transgenic mice expressing the wild-type p53 under the control of the metallothionein I promoter. In the three transgenic lines established, exogenous p53 is expressed constitutively in the postmeiotic cells of transgenic males and two lines are subfertile. Transgenic males expressing the upper level of p53 produce few spermatozoa since the majority of developing spermatids undergo apoptosis. In the subfertile males exhibiting an intermediate amount of p53, teratozoospermia is obvious suggesting an altered terminal differentiation of postmeiotic cells. In contrast lower level of p53 does not lead the third line to sterility. These results suggest that the activity of p53 is dependent in vivo on the amount of p53 present within cells, as it has been already demonstrated in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.