ArticleOncogene1999
The roles of caspase-3 and bcl-2 in chemically-induced apoptosis but not necrosis of renal epithelial cells.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 78 citations in OpenAlex.
- Sigma-1 Receptor in Retina: Neuroprotective Effects and Potential Mechanisms.International journal of molecular sciences · 2022Review
- Elucidation of the Molecular Mechanisms Underlying Sorafenib-Induced Hepatotoxicity.Oxidative medicine and cellular longevity · 2020Article
- Quantum biological tunnel junction for electron transfer imaging in live cells.Nature communications · 2019Article
- Review
- Multiple Targets of 3-Dehydroxyceanothetric Acid 2-Methyl Ester to Protect Against Cisplatin-Induced Cytotoxicity in Kidney Epithelial LLC-PK1 Cells.Molecules (Basel, Switzerland) · 2019Article
- Intradermal delivery of DNA encoding HCV NS3 and perforin elicits robust cell-mediated immunity in mice and pigs.Gene therapy · 2016Article
- The NADPH oxidase NOX5 protects against apoptosis in ALK-positive anaplastic large-cell lymphoma cell lines.Free radical biology & medicine · 2015Article
- Baicalein reduces the occurrence of cirrhotic endotoxemia by reducing intestinal mucosal apoptosis.BMC complementary and alternative medicine · 2015Article
- Sigma receptor 1 modulates ER stress and Bcl2 in murine retina.Cell and tissue research · 2014Article
- Epoxyeicosatrienoic acids prevent cisplatin-induced renal apoptosis through a p38 mitogen-activated protein kinase-regulated mitochondrial pathway.Molecular pharmacology · 2013Article
- zVAD-fmk prevents cisplatin-induced cleavage of autophagy proteins but impairs autophagic flux and worsens renal function.American journal of physiology. Renal physiology · 2012Article
- In vitro analysis of ovarian cancer response to cisplatin, carboplatin, and paclitaxel identifies common pathways that are also associated with overall patient survival.British journal of cancer · 2012Article
- Correlation of PDCD5 and apoptosis in hair cells and spiral ganglion neurons of different age of C57BL/6J mice.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2012Article
- A brain slice culture model of viral encephalitis reveals an innate CNS cytokine response profile and the therapeutic potential of caspase inhibition.Experimental neurology · 2011Article
- Royal jelly modulates oxidative stress and apoptosis in liver and kidneys of rats treated with cisplatin.Oxidative medicine and cellular longevity · 2011Article
- NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice.American journal of respiratory and critical care medicine · 2009Article
- Secondary necrosis in multicellular animals: an outcome of apoptosis with pathogenic implications.Apoptosis : an international journal on programmed cell death · 2008Review
- Effects of adaptive exercise on apoptosis in cells of rat renal tubuli.European journal of applied physiology · 2007Article
- Review
- Cisplatin nephrotoxicity: molecular mechanisms.Cancer therapy · 2003Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The kidney is a target for toxicants including cisplatin and S-(1,2-dichlorovinyl)-L-cysteine (DCVC), a metabolite of the environmental contaminant, trichloroethylene. Necrosis is well characterized in kidney cells, but pathways leading to apoptosis are less clear. Cysteine conjugates are useful toxicants because they induce either necrosis or apoptosis depending on chemical structure or antioxidant status. Herein, we show that in the renal epithelial cell line LLC-PK1, activation of caspase-3 (CPP32/Yama/apopain) is crucial for apoptosis, but not necrosis. Apoptosis was blocked by zVAD.fmk, and partially by a cathepsin inhibitor. Caspase-3 activity and cleavage of poly(ADP-ribose) polymerase (PARP) was detected only during apoptosis. S-(1,1,2,2-Tetrafluoroethyl)-L-cysteine (TFEC), a metabolite of tetrafluoroethylene, kills cells only by necrosis, and did not activate caspases under any conditions. Apoptosis and activation of caspase-3 by cisplatin, but not DCVC, was prevented by bcl-2. Thus, caspase-3 activation by bcl-2-dependent and -independent mechanisms is a terminal event in chemical-apoptosis of renal epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.