ArticleOncogene1999
CHF: a novel factor binding to cyclin A CHR corepressor element.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 39 citations in OpenAlex.
- The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes.Nucleic acids research · 2012Article
- Function of the A-type cyclins during gametogenesis and early embryogenesis.Results and problems in cell differentiation · 2011Review
- Regulation of aurora B expression by the bromodomain protein Brd4.Molecular and cellular biology · 2009Article
- Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells.Molecular and cellular biology · 2008Article
- Transcription of the human cell cycle regulated BUB1B gene requires hStaf/ZNF143.Nucleic acids research · 2007Article
- Cell cycle-dependent expression of cIAP2 at G2/M phase contributes to survival during mitotic cell cycle arrest.The Biochemical journal · 2006Article
- Cell type-dependent control of NF-Y activity by TGF-beta.Oncogene · 2006Article
- Promoter specificity and biological activity of tethered AP-1 dimers.Molecular and cellular biology · 2002Article
- Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity.Molecular and cellular biology · 2001Article
- Transactivation of murine cyclin A by polyomavirus large and small T antigens.Journal of virology · 2001Article
- Cyclin A is a mediator of p120E4F-dependent cell cycle arrest in G1.Molecular and cellular biology · 2001Article
- Cell cycle regulation of the tobacco ribonucleotide reductase small subunit gene is mediated by E2F-like elements.The Plant cell · 2000Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell cycle modulation of cyclin A expression is due to the periodic relief of a transcriptional repression mediated by a bipartite negative DNA regulatory region. The 5' element (Cell Cycle Responsive Element: CCRE; cell Cycle Dependent Element: CDE) is clearly occupied in a cyclic manner in vivo, whereas the 3' element, whose sequence is shared by B-myb, cdc25C and cdc2 genes (cell Cycle gene Homology Region: CHR), is involved in more subtle interactions. Mutation of either element results in complete deregulation of cyclin A promoter activity. Whereas some reports claim that E2F/DP can bind to the CCRE/CDE, the nature of the protein(s) interacting with the CHR is unknown. In the present work we have characterized an activity present in quiescent cells and absent in cells blocked in S phase, which binds specifically to cyclin A CHR, but not to B-myb, or to cdc25C, or to cdc2 CHRs. A 90 kD protein, named CHF (cyclin A CHR binding factor), has been identified through preparative electrophoresis and UV crosslinking experiments. In order to address in more functional terms the binding of CHF to cyclin A CHR, we developed in vitro and in vivo oligonucleotide competition assays. Both in vitro transcription and in vivo microinjection experiments demonstrate that a functional difference exists between the composite CCRE/CDE-CHR repressor regions of cell cycle regulated genes such as cyclin A and cdc25C.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.