ArticleThe American journal of pathology1999
Microsatellite instability in adenomas as a marker for hereditary nonpolyposis colorectal cancer.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Accuracy of MSI testing in predicting germline mutations of MSH2 and MLH1: a case study in Bayesian meta-analysis of diagnostic tests without a gold standard.Biostatistics (Oxford, England) · 2005Pooled it
- Article
- Using amide proton transfer-weighted MRI to non-invasively differentiate mismatch repair deficient and proficient tumors in endometrioid endometrial adenocarcinoma.Insights into imaging · 2021Article
- Mlh1 heterozygosity and promoter methylation associates with microsatellite instability in mouse sperm.Mutagenesis · 2021Article
- Prevalence of Mismatch Repair-Deficient Colorectal Adenoma/Polyp in Early-Onset, Advanced Cases: a Cross-Sectional Study Based on Iranian Hereditary Colorectal Cancer Registry.Journal of gastrointestinal cancer · 2021Article
- Colorectal Adenomas-Genetics and Searching for New Molecular Screening Biomarkers.International journal of molecular sciences · 2020Review
- Article
- Single-center study of Lynch syndrome screening in colorectal polyps.Hereditary cancer in clinical practice · 2019Article
- Mismatch repair deficiency commonly precedes adenoma formation in Lynch Syndrome-Associated colorectal tumorigenesis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- Advanced colorectal adenomas in patients under 45 years of age are mostly sporadic.Digestive diseases and sciences · 2014Article
- Microsatellite instability and DNA mismatch repair protein deficiency in Lynch syndrome colorectal polyps.Cancer prevention research (Philadelphia, Pa.) · 2012Article
- Genetic counseling considerations in the evaluation of families for Lynch syndrome--a review.Journal of genetic counseling · 2011Review
- Clinical relevance of microsatellite instability in colorectal cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2010Article
- Deficient DNA mismatch repair is common in Lynch syndrome-associated colorectal adenomas.The Journal of molecular diagnostics : JMD · 2009Article
- Matrix-comparative genomic hybridization from multicenter formalin-fixed paraffin-embedded colorectal cancer tissue blocks.BMC cancer · 2007Article
- Prevalence of the mismatch-repair-deficient phenotype in colonic adenomas arising in HNPCC patients: results of a 5-year follow-up study.International journal of colorectal disease · 2006Article
- Article
- Microsatellite analysis of hereditary nonpolyposis colorectal cancer-associated colorectal adenomas by laser-assisted microdissection: correlation with mismatch repair protein expression provides new insights in early steps of tumorigenesis.The Journal of molecular diagnostics : JMD · 2005Article
- Microsatellite instability of selective target genes in HNPCC-associated colon adenomas.Oncogene · 2005Article
- Article
Corrections and comments
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Authors and funding
17 authors at 11 institutions in 2 countries.
Funding
Abstract
Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common of the well-defined colorectal cancer syndromes, accounting for at least 2% of the total colorectal cancer burden and carrying a greater than 80% lifetime risk of cancer. Significant reduction in cancer morbidity and mortality can be accomplished by appropriate clinical cancer screening of HNPCC patients with mutations in mismatch repair (MMR) genes. Thus, it is desirable to identify individuals who are mutation-positive. In individuals with cancer, mutation detection can be accomplished relatively efficiently by germline mutation analysis of individuals whose cancers show microsatellite instability (MSI). This study was designed to assess the feasibility of screening colorectal adenoma patients for HNPCC in the same manner. Among 378 adenoma patients, six (1.6%) had at least one MSI adenoma. Five out of the six patients (83%) had a germline MMR gene mutation. We conclude that MSI analysis is a useful method of prescreening colorectal adenoma patients for HNPCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.