ReviewMolecular neurobiology1999
Signaling of neuronal cell death by the p75NTR neurotrophin receptor.
Review in Molecular neurobiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- A Christianson syndrome-linked deletion mutation (∆(287)ES(288)) in SLC9A6 disrupts recycling endosomal function and elicits neurodegeneration and cell death.Molecular neurodegeneration · 2016Article
- Structural characterization of the self-association of the death domain of p75(NTR.).PloS one · 2013Article
- Proneurotrophins, seizures, and neuronal apoptosis.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2010Review
- p75NTR-dependent modulation of cellular handling of reactive oxygen species.Journal of neurochemistry · 2009Article
- p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Up-regulation of p75 neurotrophin receptor (p75NTR) is associated with apoptosis in chronic pancreatitis.Digestive diseases and sciences · 2003Article
- c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation.The Journal of cell biology · 2002Article
- bcl-2 Overexpression eliminates deprivation-induced cell death of brainstem auditory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines.The Journal of experimental medicine · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neurotrophin receptor (p75NTR) is best known for mediating tropic support by participating in the formation of high-affinity nerve growth factor (NGF) receptor complexes with trkA, however, p75NTR more recently has been shown to act as a bona fide death-signaling receptor, which can signal independently of trkA. This article discusses the evidence for an active role of p75NTR in neuronal cell death and the mechanisms controlling this process, including roles for Bcl-2 family members, the c-jun stress kinase JNK, the transcription factor nuclear factor kappa B (NFkappaB), and caspases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.