ReviewDrugs1999
Balanced analgesia: what is it and what are its advantages in postoperative pain?
Review in Drugs, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- The Role of Surgical Techniques in Reducing Postoperative Pain in Abdominal Surgery: Evidence From the PROSPECT Systematic Reviews.World journal of surgery · 2025Pooled it
- Perioperative local infiltration anesthesia with ropivacaine has no effect on postoperative pain after total hip arthroplasty.Acta orthopaedica · 2015Trial
- Safety and efficacy of fast-track surgery in laparoscopic distal gastrectomy for gastric cancer: a randomized clinical trial.World journal of surgery · 2012Trial
- Opiate sparing effect of fixed combination of diclophenac and orphenadrine after unilateral total hip arthroplasty: A double-blind, randomized, placebo-controlled, multi-centre clinical trial.Wiener medizinische Wochenschrift (1946) · 2010Trial
- Lack of impact of intravenous lidocaine on analgesia, functional recovery, and nociceptive pain threshold after total hip arthroplasty.Anesthesiology · 2008Trial
- Patient-Controlled Analgesia in ICU: A Scoping Review.Journal of personalized medicine · 2026Review
- Regional Anesthesia in Children: How Do We Know It Works? A Review of a Novel Tool for Assessing the Impact of Regional Anesthesia for Pediatric Surgical Patients.Children (Basel, Switzerland) · 2025Article
- Fewer Pills for Fewer Problems: Strategies for Reducing Postoperative Opioid Prescribing Following Total Joint Arthroplasty.Arthroplasty today · 2025Article
- Opioid-Based vs Opioid-Free Anesthesia in Breast Cancer Surgery.Journal of pharmacy & bioallied sciences · 2023Article
- Continuous local anaesthetic wound infusion for postoperative pain after midline laparotomy for colorectal resection in adults.The Cochrane database of systematic reviews · 2019Review
- Description of a new approach for great auricular and auriculotemporal nerve blocks: A cadaveric study in foxes and dogs.Veterinary medicine and science · 2018Article
- Transversus Abdominis Plane Blocks with Single-Dose Liposomal Bupivacaine in Conjunction with a Nonnarcotic Pain Regimen Help Reduce Length of Stay following Abdominally Based Microsurgical Breast Reconstruction.Plastic and reconstructive surgery · 2017Article
- The evaluation of implementing smart patient controlled analgesic pump with a different infusion rate for different time duration on postoperative pain management.Journal of dental anesthesia and pain medicine · 2016Article
- Comparison of pain management after laparoscopic distal gastrectomy with and without epidural analgesia.Surgery today · 2016Article
- Finding the 'ideal' regimen for fentanyl-based intravenous patient-controlled analgesia: how to give and what to mix?Yonsei medical journal · 2014Article
- Analgesic effects of adding lidocaine to morphine pumps after orthopedic surgeries.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Postoperative analgesia in elderly patients.Drugs & aging · 2013Review
- Peri-operative ketamine with the ambulatory elastometric infusion pump as an adjuvant to manage acute postoperative pain after spinal fusion in adults: a prospective randomized trial.Korean journal of anesthesiology · 2012Article
- [New substances and applications for postoperative pain therapy].Schmerz (Berlin, Germany) · 2008Article
- Ketamine as an adjunct to postoperative pain management in opioid tolerant patients after spinal fusions: a prospective randomized trial.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concept of balanced analgesia was introduced to improve analgesic efficacy and reduce adverse effects. A large amount of clinical data has documented improved analgesia by combining different analgesics, but data on reducing adverse effects are inconclusive. Balanced analgesia should be used whenever possible, and future studies should be directed to define optimal combination regimens in individual surgical procedures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.