ArticleJournal of endocrinological investigation1999
Independent expression of serological markers of thyroid autoimmunity and hepatitis virus C infection in the general population: results of a community-based study in north-western Sardinia.
Article in Journal of endocrinological investigation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Pooled it
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- Direct-acting antivirals used in HCV-related liver disease do not affect thyroid function and autoimmunity.Journal of endocrinological investigation · 2023Article
- High prevalence of papillary thyroid carcinoma in nodular Hashimoto's thyroiditis at the first diagnosis and during the follow-up.Journal of endocrinological investigation · 2018Article
- Circulating antithyroid antibodies contribute to the decrease of glomerular filtration rate in lithium-treated patients: a longitudinal study.International journal of bipolar disorders · 2018Article
- The Sardinian Puzzle: Concentration of Major Psychoses and Suicide in the Same Sub-Regions Across One Century.Clinical practice and epidemiology in mental health : CP & EMH · 2017Article
- Bipolar disorder and antithyroid antibodies: review and case series.International journal of bipolar disorders · 2016Article
- Both thyroid autoimmunity and increased serum TSH are independent risk factors for malignancy in patients with thyroid nodules.Journal of endocrinological investigation · 2013Article
- Autoimmune manifestations in viral hepatitis.Seminars in immunopathology · 2013Review
- Hepatitis C and interferon induced thyroiditis.Journal of autoimmunity · 2010Review
- Interferon induced thyroiditis.Best practice & research. Clinical endocrinology & metabolism · 2009Review
- Risk of malignant lymphoma following viral hepatitis infection.International journal of hematology · 2008Article
- Interferon alpha treatment and thyroid dysfunction.Endocrinology and metabolism clinics of North America · 2007Review
- Fifteen-year follow-up of thyroid function in lithium patients.Journal of endocrinological investigation · 2007Article
- A case control study on psychiatric disorders in Hashimoto disease and Euthyroid Goitre: not only depressive but also anxiety disorders are associated with thyroid autoimmunity.Clinical practice and epidemiology in mental health : CP & EMH · 2005Article
- Is there anything to the reported association between Helicobacter pylori infection and autoimmune thyroiditis?Digestive diseases and sciences · 2005Article
- The link between thyroid autoimmunity (antithyroid peroxidase autoantibodies) with anxiety and mood disorders in the community: a field of interest for public health in the future.BMC psychiatry · 2004Article
- Expression of endocrine autoantibodies in chronic hepatitis C, before and after interferon-alpha therapy.Journal of endocrinological investigation · 2002Article
- Thyroid ultrasonography as a tool for detecting thyroid autoimmune diseases and predicting thyroid dsfunction in apparently healthy subjects.Journal of endocrinological investigation · 2001Article
- Prevalence of silent celiac disease in patients with autoimmune thyroiditis from Northern Sardinia.Journal of endocrinological investigation · 2001Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess the relationship between serological markers of thyroid autoimmunity and chronic hepatitis C, we surveyed the general population of two villages in the region of Sardinia, Italy, where infection with hepatitis viruses is endemic and the prevalence of autoimmune diseases is elevated. A total of 1310 subjects aged 6-88 years (65% of the total resident population) participated in the survey, and 1233 (94%; 444 males and 789 females) agreed to provide a blood sample. Autoantibodies to thyroid peroxidase (anti-TPO) were measured by radioimmunoassay; antibodies to HCV (anti-HCV) by a third generation enzyme immunoassay and borderline positive results confirmed by recombinant immunoblot assay. For both anti-HCV and anti-TPO the age- and gender-standardized prevalence rates (SPR) were calculated and the significance of the association between the two antibodies tested by Yates corrected chi2 test. The overall SPR for anti-HCV was 50.7x10(-3) (86/1,233), similar between men [49.1x10(-3) (22/444)] and women [52.3x10(-3) (64/789)]. The overall SPR for anti-TPO was 136.9x10(-3) (204/1,233), and that among women [201x10(-3) (174/789)] was almost 3-fold that among men [71.6x10(-3) (30/444)]. A concurrent anti-HCV and anti-TPO positivity was found in a small minority of subjects [8/1,233 (0.65%)], all women aged 57-81 years. The SPR for the two concurrent events was 3.3x10(-3), which was not significantly different (Yates corrected chi2 test = 0.65) from that expected under the assumption of unrelated events. To explore whether HCV infection is a risk factor for anti-TPO positivity, we designed a case-control study with anti-TPO positive subjects as the cases, and anti-TPO negative subjects as the controls. The age- and gender-adjusted odd ratio (OR) was 0.4 (95% CI 0.2,0.7), indicating a negative association. In conclusion, no evidence for epidemiological association of circulating thyroid autoantibodies and antibodies to HCV was found. Our findings do not therefore support a pathogenetic link between HCV infection and thyroid autoimmunity.
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