ArticleJapanese journal of cancer research : Gann1999
Characterization of the MEN1 gene product, menin, by site-specific polyclonal antibodies.
Article in Japanese journal of cancer research : Gann, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 19 citations in OpenAlex.
- A somatic mutation in MEN1 gene detected in periventricular nodular heterotopia tissue obtained from depth electrodes.Epilepsia · 2019Article
- New splicing mutation of MEN1 gene affecting the translocation of menin to the nucleus.Journal of endocrinological investigation · 2006Article
- Menin is a regulator of the stress response in Drosophila melanogaster.Molecular and cellular biology · 2005Article
- Multiple endocrine neoplasia type 1Burin from Mauritius: a novel MEN1 mutation.Journal of endocrinological investigation · 2001Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gene associated with multiple endocrine neoplasia type 1 (MEN 1), designated MEN1, has recently been identified. This gene shows no homology to other known genes, and its expression is not restricted to endocrine organs as estimated by northern blotting. Expression of the MEN1 gene product, menin, has been studied only in a few tissues. In this report, expression of menin in various cells and mouse tissues was studied using two polyclonal antibodies against menin. Expression of menin as a 76 kDa single protein was observed in all cell lines examined, regardless of origin. Two nuclear localization signals of the menin have been reported, but through the study of mutant menin in lymphocytes from subjects with MEN 1, impaired nuclear localization of the mutant menin was observed even though the mutant retained one of the two nuclear localization signals (NLSs). Menin was stable in vitro with a half-life of over 24 h at 37 degrees C. In the cell, the half-life of wild-type menin was about 10 h, while that of the mutant was about 2 h. The mutant rapidly disappeared from the nucleus.
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