ArticleClinical and experimental immunology1999
Gammadelta T cells in Behçet's disease (BD) and recurrent aphthous stomatitis (RAS).
Article in Clinical and experimental immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 133 citations in OpenAlex.
- Behçet's Disease: A Comprehensive Review on the Role ofInternational journal of molecular sciences · 2023Pooled it
- Finding the Needle in the Haystack: Serological and Urinary Biomarkers in Behçet's Disease: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Thalidomide has both anti-inflammatory and regulatory effects in Behcet's disease.Clinical rheumatology · 2008Trial
- γδ T Cells in Autoinflammatory Diseases.Cells · 2026Review
- PDE4 inhibitor mitigates activated CD8+ T cells through NF-κB signaling in Behçet's syndrome.Frontiers in immunology · 2026Article
- Harnessing Polymeric Dissolvable Microneedles: Precision Delivery of Therapeutics for Oral Ulcers.ACS omega · 2025Review
- Abnormal glucose and lipid metabolism promotes disrupted differentiation of T and B cell subsets in Behçet's disease.Immunotherapy advances · 2025Article
- The roles of immune cells in Behçet's disease.Advances in rheumatology (London, England) · 2023Review
- Efficacy of Oral Mucoadhesive N-Acetylcysteine Tablets in Treatment of Recurrent Aphthous Stomatitis: A Randomized Double-Blind, Placebo-Controlled Clinical Trial.Frontiers in dentistry · 2023Article
- Detection of the peripheral blood antigens and clinical value in recurrent aphthous ulcer: A cross-section study.Journal of dental sciences · 2023Article
- Management and outcomes of surgical patients with intestinal Behçet's disease and Crohn's disease in southwest China.World journal of clinical cases · 2021Article
- Advances in Management of Intestinal Behçet's Disease: A Perspective From Gastroenterologists.Journal of rheumatic diseases · 2021Review
- Neutrophil elastase and endogenous inhibitors in Behçet's disease saliva.Clinical and experimental immunology · 2020Article
- Frequencies of abnormal humoral and cellular immune component levels in peripheral blood of patients with recurrent aphthous ulceration.Journal of dental sciences · 2018Article
- Innate immune cells in the pathogenesis of primary systemic vasculitis.Rheumatology international · 2016Review
- Intestinal Behçet's Disease: A True Inflammatory Bowel Disease or Merely an Intestinal Complication of Systemic Vasculitis?Yonsei medical journal · 2016Review
- Gamma Delta (γδ) T Cells and Their Involvement in Behçet's Disease.Journal of immunology research · 2015Review
- Quantitative peripheral blood perturbations of γδ T cells in human disease and their clinical implications.Clinical reviews in allergy & immunology · 2014Review
- Etiopathogenesis of recurrent aphthous stomatitis and the role of immunologic aspects: literature review.Archivum immunologiae et therapiae experimentalis · 2014Review
- Expression of TNF-α, APRIL and BCMA in Behcet's disease.Journal of immunology research · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immunopathogenesis of BD is believed to be T cell-mediated. The objective of this study was to characterize the activation stage and cytokine profile of peripheral blood lymphocytes (PBL), with particular emphasis on gammadelta T cells. Venous blood was collected from 20 patients with BD, and for comparison, from 11 patients with RAS and from 15 healthy controls. Both the expression of activation markers (CD25, CD29, CD40 ligand, CD69 and HLA-DR) on freshly isolated PBL and T cell subsets, and the expression of intracellular cytokines (IL-4, IL-10, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha)) on mitogen-stimulated PBL and T cell subsets were analysed by double immunofluorescent staining and flow cytometry. Significantly decreased proportion of alphabeta T cells and increased proportion of gammadelta T cells, CD56+ cells and CD8+ gammadelta T cells were found in BD patients compared with healthy controls. This was also seen to a lesser extent in patients with RAS. Furthermore, in BD a significantly increased proportion of the gammadelta T cell population expressed CD69 and high levels of CD29 and were induced to produce IFN-gamma and TNF-alpha compared with healthy controls. In contrast, an increased percentage of gammadelta T cells from RAS patients was induced to produce IFN-gamma, but not TNF-alpha. These results indicate that in BD, activated gammadelta T cells, capable of producing IFN-gamma and TNF-alpha, are present in peripheral blood, suggesting that gammadelta T cells are dynamic and may be regulating immunopathogenic events.
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