ArticleClinical and experimental immunology1999
Circulating antibodies against alpha-enolase in patients with primary membranous nephropathy (MN).
Article in Clinical and experimental immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 66 citations in OpenAlex.
- Rescue From Permanent Kidney Injury in Acute Thrombosis of Both Renal Veins, the Inferior Vena Cava, and Both Iliofemoral Veins by Catheter-Based Thrombectomy.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2025Article
- Novel biomarkers and pathophysiology of membranous nephropathy: PLA2R and beyond.Clinical kidney journal · 2024Review
- The optimal anti-phospholipase A2 receptor cutoff for the diagnosis of idiopathic membranous nephropathy: a single-center retrospective study.The Korean journal of internal medicine · 2022Article
- Membranous Nephropathy and Anti-Podocytes Antibodies: Implications for the Diagnostic Workup and Disease Management.BioMed research international · 2018Review
- Circulating antibodies to α-enolase and phospholipase AClinical and experimental nephrology · 2017Article
- Anti-Phospholipase A2 Receptor (PLA2R) Antibody and Glomerular PLA2R Expression in Japanese Patients with Membranous Nephropathy.PloS one · 2016Article
- The Anti-inflammatory Effect of GV1001 Mediated by the Downregulation of ENO1-induced Pro-inflammatory Cytokine Production.Immune network · 2015Article
- Association between anti-Porphyromonas gingivalis or anti-α-enolase antibody and severity of periodontitis or rheumatoid arthritis (RA) disease activity in RA.BMC musculoskeletal disorders · 2015Article
- Glomerular autoimmune multicomponents of human lupus nephritis in vivo: α-enolase and annexin AI.Journal of the American Society of Nephrology : JASN · 2014Article
- Eukaryotic expression, purification and structure/function analysis of native, recombinant CRISP3 from human and mouse.Scientific reports · 2014Article
- Autoantibodies against phospholipase A2 receptor in Korean patients with membranous nephropathy.PloS one · 2013Article
- Coexistence of different circulating anti-podocyte antibodies in membranous nephropathy.Clinical journal of the American Society of Nephrology : CJASN · 2012Article
- Membranous nephropathy: the start of a paradigm shift.Current opinion in nephrology and hypertension · 2012Review
- Idiopathic membranous nephropathy: an autoimmune disease.Seminars in nephrology · 2011Review
- Anti-phospholipase A2 receptor antibody in membranous nephropathy.Journal of the American Society of Nephrology : JASN · 2011Article
- Sudden retinal vein thrombosis in a patient with nephrotic syndrome.BMJ case reports · 2011Article
- Isotype and IgG subclass distribution of autoantibody response to alpha-enolase protein in adult patients with severe asthma.Yonsei medical journal · 2008Article
- Analysis of IgG antibody patterns against retinal antigens and antibodies to alpha-crystallin, GFAP, and alpha-enolase in sera of patients with "wet" age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2007Article
- Circulating anti-actin and anti-ATP synthase antibodies identify a sub-set of patients with idiopathic nephrotic syndrome.Clinical and experimental immunology · 2005Article
- Natural antigenic peptides from squamous cell carcinoma recognized by autologous HLA-DR8-restricted CD4+ T cells.Japanese journal of cancer research : Gann · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MN is characterized by the glomerular deposition of IgG4 immune complexes. This suggests that nephritogenic immune responses in MN are of the Th2 T helper cell type; however, the pathogenesis of MN is still unknown. In this study we examined sera from patients with primary MN for antibodies to renal proteins. A 47-kD protein in both human and porcine renal extracts was found by immunoblotting to react specifically with serum IgG from some patients. This protein was purified from porcine kidney and identified as alpha-enolase on the basis of its partial amino acid sequences. Sera from 87 patients with primary MN, 24 patients with secondary MN (15 rheumatoid arthritis patients, nine systemic lupus erythematosus patients), and 16 healthy subjects were examined by ELISA using purified alpha-enolase. In 60 (69%) patients with primary MN and 14 (58%) patients with secondary MN, the measured optical density values, and hence serum anti-alpha-enolase antibody levels, were greater than the mean + 2 s.d. of healthy subjects. Immunoblot analysis showed that IgG1 or IgG3 was the predominant subclass (Th1 T helper cell type subclass) of antibodies against alpha-enolase in patients with primary and secondary MN. Since circulating antibodies against alpha-enolase have recently been reported in patients with various autoimmune disorders, our results suggest that a number of patients with presumed primary MN may also have abnormalities in Th1 T helper cell-mediated immune responses.
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