SynthesisBritish journal of clinical pharmacology1999
Placebo effect in the treatment of duodenal ulcer.
Synthesis in British journal of clinical pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Does the placebo effect on hot flashes depend on the placebo dose?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Pooled it
- Meta-analysis: the effects of placebo treatment on gastro-oesophageal reflux disease.Alimentary pharmacology & therapeutics · 2010Pooled it
- The effect of solifenacin on postvoid dribbling in women: results of a randomized, double-blind placebo-controlled trial.International urogynecology journal · 2018Trial
- Efficacy and Safety of Selexipag in Adults With Raynaud's Phenomenon Secondary to Systemic Sclerosis: A Randomized, Placebo-Controlled, Phase II Study.Arthritis & rheumatology (Hoboken, N.J.) · 2017Trial
- Trial
- Boosting open-label placebo effects in acute induced pain in healthy adults (BOLPAP-study): study protocol of a randomized controlled trial.Frontiers in medicine · 2024Article
- A Dose of Reality About Dose-Response Relationships.Journal of general internal medicine · 2023Review
- TIDieR-Placebo: A guide and checklist for reporting placebo and sham controls.PLoS medicine · 2020Article
- Placebo Responses and Placebo Effects in Functional Gastrointestinal Disorders.Frontiers in psychiatry · 2020Review
- The Art of Surgery: The Strange World of the Placebo Response.Global spine journal · 2019Article
- Placebos as a Source of Agency: Evidence and Implications.Frontiers in psychiatry · 2019Review
- The Myth of the Placebo Response.Frontiers in psychiatry · 2019Article
- Administration of the Tablet Formulation of Olaparib in Patients with Ovarian Cancer: Practical Guidance and Expectations.The oncologist · 2018Review
- What trial participants need to be told about placebo effects to give informed consent: a survey to establish existing knowledge among patients with back pain.Journal of medical ethics · 2017Article
- Age and sex as moderators of the placebo response – an evaluation of systematic reviews and meta-analyses across medicine.Gerontology · 2015Review
- Acupuncture for the treatment of hot flashes in patients with breast cancer receiving antiestrogen therapy: a pilot study in Korean women.Journal of alternative and complementary medicine (New York, N.Y.) · 2013Article
- Restoring psychology's role in peptic ulcer.Applied psychology. Health and well-being · 2013Review
- Can an educational handout enhance placebo analgesia for experimentally-induced pain?PloS one · 2013Article
- A systematic review of the effect of expectancy on treatment responses to acupuncture.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Reframing placebo in research and practice.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo assess whether frequency of placebo administration is associated with duodenal ulcer healing.
methodsA systematic literature review of randomized clinical trials was undertaken. 79 of 80 trials that met the inclusion criteria. The pooled 4 week placebo healing rate of all duodenal ulcer trials that employed a four times a day regimen was compared with the rate obtained from trials with a twice a day regimen.
resultsThe pooled 4 week healing rate of the 51 trials with a four times a day regimen was 44. 2% (805 of 1821 patients) compared with 36.2% (545 of 1504 patients) in the 28 trials with a twice a day regimen (difference, 8.0% [equal effects model]; 95% confidence interval, 4.6% to 11.3%). Depending on the statistical analysis, the rate difference ranged from 6.0% (multivariable random effects model) to 8.0% (equal effects model). A number of sensitivity analyses showed comparable differences between the two regimens. Most of these sensitivity analyses were not significant, probably because a number of trials were excluded resulting in a loss of power.
conclusionsWe found a relation between frequency of placebo administration and healing of duodenal ulcer. We realize that the comparison was based on nonrandomized data. However, we speculate that the difference between regimens was induced by the difference in frequency of placebo administration. A better knowledge of various placebo effects is required in order to make clinically relevant assessments of treatment effects derived from placebo-controlled trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.