ArticleBritish journal of clinical pharmacology1999
Cutaneous reactions to drugs. An analysis of spontaneous reports in four Italian regions.
Article in British journal of clinical pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Human Skin Aging: Physiology and Pathophysiology.Biology · 2026Article
- Insights into Severe Cutaneous Adverse Drug Reactions: A 5-Year Retrospective Analysis of Stevens- Johnson Syndrome- Toxic Epidermal Necrolysis and Drug Rash with Eosinophilia and Systemic Symptoms.Indian dermatology online journal · 2026Article
- Three maxims for countering sex essentialism in scientific research.Biology of sex differences · 2025Review
- Evaluation of severe adverse cutaneous drug reactions in patients admitted to tertiary care center: A cross-sectional study.Health science reports · 2024Article
- Article
- Macrolide Allergic Reactions.Pharmacy (Basel, Switzerland) · 2019Review
- Spontaneous cutaneous adverse drug reaction reports-An analysis of a 10-year dataset in Singapore.Pharmacology research & perspectives · 2019Article
- Phenotypes of Severe Cutaneous Adverse Reactions Caused by Nonsteroidal Anti-inflammatory Drugs.Allergy, asthma & immunology research · 2019Article
- HLA-BFrontiers in neurology · 2019Article
- A pilot study on the incidence of severe photosensitivity reactions leading to hospitalization linked to topical ketoprofen and other medications in selected European regions.Pharmacology research & perspectives · 2016Article
- Retrospective Analysis of Pattern of Cutaneous Adverse Drug Reactions in Tertiary Hospital of Pauri Garhwal.Journal of clinical and diagnostic research : JCDR · 2016Article
- Morphological Pattern of Cutaneous Adverse Drug Reactions due to Antiepileptic Drugs in Eastern India.Journal of clinical and diagnostic research : JCDR · 2015Article
- Cutaneous adverse drug reactions in Indian population: A systematic review.Indian dermatology online journal · 2014Article
- Cutaneous adverse drug reactions in the elderly: a retrospective analysis in Thailand.Drugs & aging · 2014Article
- Adverse cutaneous drug reactions: Eight year assessment in hospitalized patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Piroxicam-β-cyclodextrin: a GI safer piroxicam.Current medicinal chemistry · 2013Review
- Cutaneous adverse drug reactions in a tertiary care teaching hospital: A North Indian perspective.International journal of applied & basic medical research · 2011Article
- Ibuprofen: pharmacology, efficacy and safety.Inflammopharmacology · 2009Review
- UV-Vis spectrophotometrical and analytical methodology for the determination of singlet oxygen in new antibacterials drugs.Analytical chemistry insights · 2007Article
- Use and safety profile of antiepileptic drugs in Italy.European journal of clinical pharmacology · 2007Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsCutaneous manifestations are frequently reported in association with drug use. The aim of this study was to analyse the skin reactions reported to the spontaneous surveillance systems of four Italian regions (Friuli Venezia Giulia, Lombardy, Sicily and the Veneto), and correlate the reports with estimated drug consumption during the same period, paying particular attention to the reactions to antimicrobial agents and nonsteroidal anti-inflammatory drugs (NSAIDs).
methodsAll of the adverse drug reactions (ADRs) reported spontaneously between January 1996 and December 1997 to the surveillance systems of four Italian regions (a total population of about 20 million people) were analysed by a panel of experts including dermatologists. On the basis of the Critical Term List of the World Health Organization (WHO), the reactions were classified as either serious or nonserious events. Drug consumption was expressed as a daily defined dose (DDD)/1000 inhabitants/day.
resultsA total of 2224 adverse skin reaction reports (44.7% of all of the reported ADRs) were identified, making a reporting rate of about 5.5 per 100 000 inhabitants/year. The female/male ratio was 1.58, and the reporting rate progressively increased with age. The drug categories with the highest number of cutaneous reactions were antimicrobials, followed by NSAIDs, analgesics and radiology contrast media. There was a total of 372 (16.9%) serious reaction reports, the most frequent being angioedema (171 cases), erythema multiforme (68 cases) and photosensitivity (37 cases). Co-trimoxazole, followed by the cephalosporins and fluoroquinolones, were associated with the highest consumption-related reporting rate among the antimicrobials, and aspirin and dipyrone among the NSAIDs and analgesics.
conclusionsSpontaneous reports from four Italian regions revealed that the skin was the organ most frequently affected by ADRs. The paper shows the validity of a regional decentralized system in Italy.
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