Trial reportBritish journal of clinical pharmacology1999
Population frequency, mutation linkage and analytical methodology for the Arg16Gly, Gln27Glu and Thr164Ile polymorphisms in the beta2-adrenergic receptor among Turks.
Trial report in British journal of clinical pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 50 citations in OpenAlex.
- Frequencies of the Arg16Gly, Gln27Glu and Thr164Ile Adrenoceptor β2 Polymorphisms among Omanis.Sultan Qaboos University medical journal · 2015Article
- Evaluation of spirometry values in relation to beta-2-adrenergic receptor gene polymorphism.European journal of medical research · 2010Article
- Influence of beta2-adrenoceptor gene polymorphisms on beta2-adrenoceptor-mediated responses in human lung mast cells.British journal of pharmacology · 2007Article
- Novel human alpha1a-adrenoceptor single nucleotide polymorphisms alter receptor pharmacology and biological function.Naunyn-Schmiedeberg's archives of pharmacology · 2005Article
- Beta-adrenoceptor polymorphisms.Naunyn-Schmiedeberg's archives of pharmacology · 2004Review
- Beta 2-adrenergic receptor polymorphism and susceptibility to primary congenital and primary open angle glaucoma.European journal of clinical pharmacology · 2003Article
- Genetic polymorphisms of adrenergic receptors.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2001Review
- Regulation of mast cells by beta-agonists.Clinical reviews in allergy & immunologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsInherited polymorphisms of codons 16, 27, and 164 of the beta2-adrenergic receptor (B2AR) gene may result in significantly changed functions of this receptor. The aim of the present study was to investigate the frequencies of the main mutations of the B2AR gene in Turks.
methodsA group of 104 unrelated Turkish subjects were analysed for the Arg16Gly, Gln27Glu, and Thr164Leu polymorphisms of B2AR by a newly designed polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. A 242-bp amplicon including the Arg16Gly and Gln27Glu polymorphisms was generated including an arbitrary restriction site, allowing the cleavage with Eco130I or Fnu4HI for analysis of the two polymorphic sites, respectively. For the amino acid polymorphism at codon 164 a 280-bp fragment was generated and digested by MnlI.
resultsThe allelic frequencies of mutated Gly16, Glu27, and Ile164 alleles were found as 59.6%, 31.7%, and 0.5%, respectively. Although, the frequencies of the polymorphisms at codon 16 and 164 were found similar as in various Caucasian populations, the frequency of the Glu27 variant was found significantly lower than these populations.
conclusionsObviously there are interethnic differences in functionally relevant B2AR variants which may have implications for drug treatment and disease susceptibility.
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