ArticlePlant physiology1999
Increased respiratory restriction during phosphate-limited growth in transgenic tobacco cells lacking alternative oxidase.
Article in Plant physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 146 citations in OpenAlex.
- Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings.Plant, cell & environment · 2026Article
- Genome-wide identification of AOX family genes in Moso bamboo and functional analysis of PeAOX1b_2 in drought and salinity stress tolerance.Plant cell reports · 2022Article
- Alternative oxidase (AOX) in the carnivorous pitcher plants of the genus Nepenthes: what is it good for?Annals of botany · 2022Article
- In Vivo Metabolic Regulation of Alternative Oxidase under Nutrient Deficiency-Interaction with Arbuscular Mycorrhizal Fungi andInternational journal of molecular sciences · 2020Review
- Roles for Plant Mitochondrial Alternative Oxidase Under Normoxia, Hypoxia, and Reoxygenation Conditions.Frontiers in plant science · 2020Article
- Article
- Comparison of the response of alternative oxidase and uncoupling proteins to bacterial elicitor induced oxidative burst.PloS one · 2019Article
- Alternative Oxidase Isoforms Are Differentially Activated by Tricarboxylic Acid Cycle Intermediates.Plant physiology · 2018Article
- Rosmarinic acid induces programmed cell death in Arabidopsis seedlings through reactive oxygen species and mitochondrial dysfunction.PloS one · 2018Article
- Unraveling the Initial Plant Hormone Signaling, Metabolic Mechanisms and Plant Defense Triggering the Endomycorrhizal Symbiosis Behavior.Frontiers in plant science · 2018Review
- Molecular Evolution of Alternative Oxidase Proteins: A Phylogenetic and Structure Modeling Approach.Journal of molecular evolution · 2016Article
- Alternative Oxidase Pathway Optimizes Photosynthesis During Osmotic and Temperature Stress by Regulating Cellular ROS, Malate Valve and Antioxidative Systems.Frontiers in plant science · 2016Article
- Nitric oxide induces the alternative oxidase pathway in Arabidopsis seedlings deprived of inorganic phosphate.Journal of experimental botany · 2015Article
- Silicon does not mitigate cell death in cultured tobacco BY-2 cells subjected to salinity without ethylene emission.Plant cell reports · 2015Article
- Cytokinin-induced cell death is associated with elevated expression of alternative oxidase in tobacco BY-2 cells.Protoplasma · 2013Article
- Overexpression of alternative oxidase gene confers aluminum tolerance by altering the respiratory capacity and the response to oxidative stress in tobacco cells.Molecular biotechnology · 2013Article
- Alternative oxidase: a mitochondrial respiratory pathway to maintain metabolic and signaling homeostasis during abiotic and biotic stress in plants.International journal of molecular sciences · 2013Review
- Cyclin-dependent kinase E1 (CDKE1) provides a cellular switch in plants between growth and stress responses.The Journal of biological chemistry · 2013Article
- Extending cassava root shelf life via reduction of reactive oxygen species production.Plant physiology · 2012Article
- The ascorbate-glutathione-α-tocopherol triad in abiotic stress response.International journal of molecular sciences · 2012Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We found that mitochondrial alternative oxidase (AOX) protein and the capacity for CN-resistant respiration are dramatically increased in wild-type tobacco (Nicotiana tabacum) suspension-cultured cells in response to growth under P limitation, and antisense (AS8) tobacco cells unable to induce AOX under these conditions have altered growth and metabolism. Specifically, we found that the respiration of AS8 cells was restricted during P-limited growth, when the potential for severe adenylate control of respiration (at the level of C supply to the mitochondrion and/or at the level of oxidative phosphorylation) is high due to the low cellular levels of ADP and/or inorganic P. As a result of this respiratory restriction, AS8 cells had altered growth, morphology, cellular composition, and patterns of respiratory C flow to amino acid synthesis compared with wild-type cells with abundant AOX protein. Also, AS8 cells under P limitation displayed high in vivo rates of generation of active oxygen species compared with wild-type cells. This difference could be abolished by an uncoupler of mitochondrial oxidative phosphorylation. Our results suggest that induction of non-phosphorylating AOX respiration (like induction of adenylate and inorganic P-independent pathways in glycolysis) is an important plant metabolic adaptation to P limitation. By preventing severe respiratory restriction, AOX acts to prevent both redirections in C metabolism and the excessive generation of harmful active oxygen species in the mitochondrion.
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