ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Upregulation of GABA neurotransmission suppresses hippocampal excitability and prevents long-term potentiation in transgenic superoxide dismutase-overexpressing mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 52 citations in OpenAlex.
- Comparison of Superoxide Dismutase Activity at the Cell, Organ, and Whole-Body Levels.Cell biochemistry and biophysics · 2025Review
- Simultaneous intrathecal injection of muscimol and endomorphin-1 alleviates neuropathic pain in rat model of spinal cord injury.Brain and behavior · 2020Article
- Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome.Neurobiology of disease · 2017Article
- Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues.PloS one · 2015Article
- Interleukin-1β promotes long-term potentiation in patients with multiple sclerosis.Neuromolecular medicine · 2014Article
- Synaptic plasticity and PDGF signaling defects underlie clinical progression in multiple sclerosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Repeated administration of PEP-1-Cu,Zn-superoxide dismutase and PEP-1-peroxiredoxin-2 to senescent mice induced by D-galactose improves the hippocampal functions.Neurochemical research · 2013Article
- Inflammation subverts hippocampal synaptic plasticity in experimental multiple sclerosis.PloS one · 2013Article
- Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome.Current opinion in neurobiology · 2012Article
- Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome.Neurobiology of disease · 2012Article
- Alpha5GABAA receptor activity sets the threshold for long-term potentiation and constrains hippocampus-dependent memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- A knock-in reporter model of Batten disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Enhancement of Cognitive and Electrophysiological Measures of Hippocampal Functioning in Rats by a Low, But Not High, Dose of Dehydroepiandrosterone Sulfate (DHEAS).Nonlinearity in biology, toxicology, medicine · 2004Article
- Hydrogen peroxide as a diffusible signal molecule in synaptic plasticity.Molecular neurobiology · 2004Review
- Paradoxical actions of hydrogen peroxide on long-term potentiation in transgenic superoxide dismutase-1 mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Absence of long-term depression in the visual cortex of glutamic Acid decarboxylase-65 knock-out mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Suppression of neuronal hyperexcitability and associated delayed neuronal death by adenoviral expression of GABA(C) receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cu/Zn superoxide dismutase (SOD-1) is a key enzyme in oxygen metabolism in the brain. Overexpression of SOD-1 in transgenic (Tg) mice has been used to study the functional roles of this enzyme in oxidative stress, lipid peroxidation, and neurotoxicity. We found that Tg-SOD-1 mice are strikingly less sensitive to kainic acid-induced behavioral seizures than control mice. Furthermore, the hippocampus of Tg-SOD-1 mice was far less sensitive to local application of bicuculline, a GABA-A antagonist, than the hippocampus of control mice. GABAergic functions, expressed in extracellular paired-pulse depression, and in IPSCs recorded in dentate granular cells were enhanced in Tg-SOD-1 mice. Finally, long-term potentiation (LTP), not found in the dentate gyrus of Tg-SOD-1 mice, could be restored by local blockade of inhibition and could be blocked in control mice by injection of diazepam, which amplifies inhibition. These results indicate that constitutive elevation of SOD-1 activity exerts a major effect on neuronal excitability in the hippocampus, which, in turn, controls hippocampal ability to express LTP.
Indexed as
Identifiers
10594078PMC6784966W1916977874What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.