ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Differences in expression of acetylcholinesterase and collagen Q control the distribution and oligomerization of the collagen-tailed forms in fast and slow muscles.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 70 citations in OpenAlex.
- Effects ofAnimals : an open access journal from MDPI · 2025Article
- Molecular Analysis of a Congenital Myasthenic Syndrome Due to a Pathogenic Variant Affecting the C-Terminus of ColQ.International journal of molecular sciences · 2023Article
- AChR β-Subunit mRNAs Are Stabilized by HuR in a Mouse Model of Congenital Myasthenic Syndrome With Acetylcholinesterase Deficiency.Frontiers in molecular neuroscience · 2020Article
- Gene Expression Profile at the Motor Endplate of the Neuromuscular Junction of Fast-Twitch Muscle.Frontiers in molecular neuroscience · 2020Article
- In Vitro Innervation as an Experimental Model to Study the Expression and Functions of Acetylcholinesterase and Agrin in Human Skeletal Muscle.Molecules (Basel, Switzerland) · 2017Review
- Acetylcholinesterase deficiency contributes to neuromuscular junction dysfunction in type 1 diabetic neuropathy.American journal of physiology. Endocrinology and metabolism · 2012Article
- Protein-anchoring strategy for delivering acetylcholinesterase to the neuromuscular junction.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Article
- Anti-MuSK autoantibodies block binding of collagen Q to MuSK.Neurology · 2011Article
- Molecular Assembly and Biosynthesis of Acetylcholinesterase in Brain and Muscle: the Roles of t-peptide, FHB Domain, and N-linked Glycosylation.Frontiers in molecular neuroscience · 2011Article
- ColQ controls postsynaptic differentiation at the neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The effects of exercise-induced fatigue on acetylcholinesterase expression and activity at rat neuromuscular junctions.Acta histochemica et cytochemica · 2009Article
- Dissociation of transcription, translation, and assembly of collagen-tailed acetylcholinesterase in skeletal muscle.The Journal of biological chemistry · 2009Article
- Acetylcholinesterase mobility and stability at the neuromuscular junction of living mice.Molecular biology of the cell · 2007Article
- Transcriptional control of different acetylcholinesterase subunits in formation and maintenance of vertebrate neuromuscular junctions.Journal of molecular neuroscience : MN · 2006Article
- MuSK is required for anchoring acetylcholinesterase at the neuromuscular junction.The Journal of cell biology · 2004Article
- ATP acts via P2Y1 receptors to stimulate acetylcholinesterase and acetylcholine receptor expression: transduction and transcription control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Expression of the P2Y1 nucleotide receptor in chick muscle: its functional role in the regulation of acetylcholinesterase and acetylcholine receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The collagen-tailed forms of acetylcholinesterase (AChE) are accumulated at mammalian neuromuscular junctions. The A(4), A(8), and A(12) forms are expressed differently in the rat fast and slow muscles; the sternomastoid muscle contains essentially the A(12) form at end plates, whereas the soleus muscle also contains extrajunctional A(4) and A(8) forms. We show that collagen Q (ColQ) transcripts become exclusively junctional in the adult sternomastoid but remain uniformly expressed in the soleus. By coinjecting Xenopus oocytes with AChE(T) and ColQ mRNAs, we reproduced the muscle patterns of collagen-tailed forms. The soleus contains transcripts ColQ1 and ColQ1a, whereas the sternomastoid only contains ColQ1a. Collagen-tailed AChE represents the first evidence that synaptic components involved in cholinergic transmission may be differently regulated in fast and slow muscles.
Indexed as
Identifiers
10594051PMC6784926W1956905194What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.