ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Long-term depression of excitatory synaptic transmission in the rat amygdala.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
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Who cites it
22 citing papers in PubMed.
- Heterotopic low-frequency stimulation induces nociceptive LTD within the same central receptive field in man.Experimental brain research · 2011Trial
- Fear conditioning and extinction distinctively alter bidirectional synaptic plasticity within the amygdala of an animal model of post-traumatic stress disorder.Neurobiology of stress · 2024Article
- Boosting Psychotherapy With Noninvasive Brain Stimulation: The Whys and Wherefores of Modulating Neural Plasticity to Promote Therapeutic Change.Neural plasticity · 2024Review
- Specific behaviors during auditory fear conditioning and postsynaptic expression of AMPA receptors in the basolateral amygdala predict interindividual differences in fear generalization in male rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
- Sex-specific divergent maturational trajectories in the postnatal rat basolateral amygdala.iScience · 2022Article
- N-acetylcysteine facilitates extinction of cued fear memory in rats via reestablishing basolateral amygdala glutathione homeostasis.Acta pharmacologica Sinica · 2022Article
- Astrocytes in Neural Circuits: Key Factors in Synaptic Regulation and Potential Targets for Neurodevelopmental Disorders.Frontiers in molecular neuroscience · 2021Review
- Potential Role of Synaptic Activity to Inhibit LTD Induction in Rat Visual Cortex.Neural plasticity · 2016Article
- Bidirectional regulation of synaptic plasticity in the basolateral amygdala induced by the D1-like family of dopamine receptors and group II metabotropic glutamate receptors.The Journal of physiology · 2014Article
- Low-frequency stimulation induces long-term depression and slow onset long-term potentiation at perforant path-dentate gyrus synapses in vivo.Journal of neurophysiology · 2014Article
- Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala.Frontiers in molecular neuroscience · 2014Article
- Mechanisms contributing to the induction and storage of Pavlovian fear memories in the lateral amygdala.Learning & memory (Cold Spring Harbor, N.Y.) · 2013Article
- Low-frequency stimulation depresses the primate anterior-cingulate-cortex and prevents spontaneous recovery of aversive memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Metabotropic glutamate receptors: from the workbench to the bedside.Neuropharmacology · 2011Review
- Metabotropic glutamate receptor-mediated long-term depression: molecular mechanisms.Pharmacological reviews · 2009Review
- A biologically realistic network model of acquisition and extinction of conditioned fear associations in lateral amygdala neurons.Journal of neurophysiology · 2009Article
- Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis.Learning & memory (Cold Spring Harbor, N.Y.) · 2007Article
- The physiological role of kainate receptors in the amygdala.Molecular neurobiology · 2004Review
- Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Neocortical long-term potentiation and long-term depression: site of expression investigated by infrared-guided laser stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In view of the fact that both kindling and fear-potentiated startle are expressed by long-term enhancement of synaptic transmission in the amygdala, synaptic plasticity in this area of the brain is of particular importance. Here, we show for the first time that low-frequency stimulation of the lateral nucleus at 1 Hz for 15 min elicited a long-term depression (LTD) in the basolateral amygdala (BLA) neurons. LTD is expressed specifically at the lateral-BLA synapses but not at ventral endopyriform nucleus-BLA synapses. The induction of LTD requires activation of both NMDA and metabotropic glutamate receptors. Loading cells with a Ca(2+) chelator BAPTA or extracellular superfusion with protein phosphatase inhibitors prevents LTD, suggesting that LTD may result from dephosphorylation of AMPA receptors. The same stimulating protocol could not elicit LTD in neurons from kindled animals, whereas neurons from sham-operated or age-matched control rats were able to exhibit LTD. Together, this study characterizes the properties of LTD in the naïve amygdala slices for the first time and demonstrates that epileptogenesis in vivo induces disruption of LTD in the in vitro preparation.
Indexed as
Identifiers
10594049PMC6784950What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.