ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Similarities and differences between the responses of rat sensory neurons to noxious heat and capsaicin.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 124 citations in OpenAlex.
- TRPV2: a universal regulator in cellular physiology with a yet poorly defined thermosensitivity.The journal of physiological sciences : JPS · 2024Review
- A journey from molecule to physiology andFrontiers in pharmacology · 2023Review
- TRPV1 feed-forward sensitisation depends on COX2 upregulation in primary sensory neurons.Scientific reports · 2021Article
- Use Dependence of Heat Sensitivity of Vanilloid Receptor TRPV2.Biophysical journal · 2016Article
- Heat and AITC activate green anole TRPA1 in a membrane-delimited manner.Pflugers Archiv : European journal of physiology · 2014Article
- Anandamide produced by Ca(2+)-insensitive enzymes induces excitation in primary sensory neurons.Pflugers Archiv : European journal of physiology · 2014Article
- The basal thermal sensitivity of the TRPV1 ion channel is determined by PKCβII.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The Useage of Opioids and their Adverse Effects in Gastrointestinal Practice: A Review.Middle East journal of digestive diseases · 2013Review
- The thermo-TRP ion channel family: properties and therapeutic implications.British journal of pharmacology · 2012Review
- Calcium-dependent decrease in the single-channel conductance of TRPV1.Pflugers Archiv : European journal of physiology · 2011Article
- Kinetic and energetic analysis of thermally activated TRPV1 channels.Biophysical journal · 2010Article
- Capsaicin-sensitive primary sensory neurons in the mouse express N-Acyl phosphatidylethanolamine phospholipase D.Neuroscience · 2009Article
- Tunable calcium current through TRPV1 receptor channels.The Journal of biological chemistry · 2008Article
- The differential expression of low-threshold K+ currents generates distinct firing patterns in different subtypes of adult mouse trigeminal ganglion neurones.The Journal of physiology · 2008Article
- Lack of potentiating effect of increasing temperature on responses to chemical activators in vagal sensory neurons isolated from TRPV1-null mice.American journal of physiology. Lung cellular and molecular physiology · 2008Article
- Termination zones of functionally characterized spinothalamic tract neurons within the primate posterior thalamus.Journal of neurophysiology · 2008Article
- Temperature sensing across species.Pflugers Archiv : European journal of physiology · 2007Review
- Thermodynamics of heat activation of single capsaicin ion channels VR1.Biophysical journal · 2003Article
- Single-channel properties of native and cloned rat vanilloid receptors.The Journal of physiology · 2002Article
- Prostaglandin and protein kinase A-dependent modulation of vanilloid receptor function by metabotropic glutamate receptor 5: potential mechanism for thermal hyperalgesia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have compared the membrane response of rat primary sensory neurons to capsaicin and noxious heat, using electrophysiological and ion flux measurements. Our aim was to determine whether, as recently proposed, the same molecular entity accounts for excitation by both types of stimulus. The properties of the ion channels activated by heat and capsaicin show many similarities but also important differences. The calcium permeability of heat-activated channels is lower than that of capsaicin-activated channels. Distinct single channels respond to heat or capsaicin, and only a few show dual sensitivity. At the whole-cell level, individual cells invariably show dual sensitivity, but the amplitudes of the responses show little correlation. We conclude that distinct molecular entities, which are both likely to be derived from the VR1 gene product, account for the membrane responses to heat and capsaicin.
Indexed as
Identifiers
10594048PMC6784946W2128640372What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.