ArticleNucleic acids research2000
WIT: integrated system for high-throughput genome sequence analysis and metabolic reconstruction.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed.
- Evolution of networks of protein domain organization.Scientific reports · 2021Article
- Review of Machine Learning Methods for the Prediction and Reconstruction of Metabolic Pathways.Frontiers in molecular biosciences · 2021Review
- Reduced network extremal ensemble learning (RenEEL) scheme for community detection in complex networks.Scientific reports · 2019Article
- Spreading to localized targets in complex networks.Scientific reports · 2016Article
- Exploring Spatio-temporal Dynamics of Cellular Automata for Pattern Recognition in Networks.Scientific reports · 2016Article
- Functional Annotations of Paralogs: A Blessing and a Curse.Life (Basel, Switzerland) · 2016Article
- Molecular and genetic inflammation networks in major human diseases.Molecular bioSystems · 2016Review
- The early history and emergence of molecular functions and modular scale-free network behavior.Scientific reports · 2016Article
- From DNA to FBA: How to Build Your Own Genome-Scale Metabolic Model.Frontiers in microbiology · 2016Article
- Analysis of the enzyme network involved in cattle milk production using graph theory.Molecular biology research communications · 2015Article
- Comparative phylogenomics and evolution of the Brucellae reveal a path to virulence.Journal of bacteriology · 2014Article
- Synergies between RNA degradation and trans-translation in Streptococcus pneumoniae: cross regulation and co-transcription of RNase R and SmpB.BMC microbiology · 2012Article
- A network-based approach to classify the three domains of life.Biology direct · 2011Article
- Systems metabolic engineering: genome-scale models and beyond.Biotechnology journal · 2010Review
- Reconstruction and validation of RefRec: a global model for the yeast molecular interaction network.PloS one · 2010Article
- HPD: an online integrated human pathway database enabling systems biology studies.BMC bioinformatics · 2009Article
- Efficient reconstruction of metabolic pathways by bidirectional chemical search.Bulletin of mathematical biology · 2009Article
- Genomics of bacteria and archaea: the emerging dynamic view of the prokaryotic world.Nucleic acids research · 2008Review
- Glycerate 2-kinase of Thermotoga maritima and genomic reconstruction of related metabolic pathways.Journal of bacteriology · 2008Article
- SPIKE--a database, visualization and analysis tool of cellular signaling pathways.BMC bioinformatics · 2008Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The WIT (What Is There) (http://wit.mcs.anl.gov/WIT2/) system has been designed to support comparative analysis of sequenced genomes and to generate metabolic reconstructions based on chromosomal sequences and metabolic modules from the EMP/MPW family of databases. This system contains data derived from about 40 completed or nearly completed genomes. Sequence homologies, various ORF-clustering algorithms, relative gene positions on the chromosome and placement of gene products in metabolic pathways (metabolic reconstruction) can be used for the assignment of gene functions and for development of overviews of genomes within WIT. The integration of a large number of phylogenetically diverse genomes in WIT facilitates the understanding of the physiology of different organisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.