ArticleJournal of neurocytology1999
Association of actin filaments with axonal microtubule tracts.
Article in Journal of neurocytology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Neural bottlenecks: axon count, distribution, and conduction in the Manduca sexta neck connective.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Article
- The Giant Axon of the Squid: A Simple System for Axonal Transport Studies.Methods in molecular biology (Clifton, N.J.) · 2022Article
- An Integrated Cytoskeletal Model of Neurite Outgrowth.Frontiers in cellular neuroscience · 2018Review
- The nano-architecture of the axonal cytoskeleton.Nature reviews. Neuroscience · 2017Review
- Axonal actin in action: Imaging actin dynamics in neurons.Methods in cell biology · 2016Article
- A dynamic formin-dependent deep F-actin network in axons.The Journal of cell biology · 2015Article
- Drag of the cytosol as a transport mechanism in neurons.Biophysical journal · 2014Article
- Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon.Physical biology · 2012Article
- The axonal transport of mitochondria.Journal of cell science · 2012Review
- Ndel1-derived peptides modulate bidirectional transport of injected beads in the squid giant axon.Biology open · 2012Article
- Myosin Va increases the efficiency of neurofilament transport by decreasing the duration of long-term pauses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- A peptide zipcode sufficient for anterograde transport within amyloid precursor protein.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Role of actin filaments in the axonal transport of microtubules.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of alzheimer's disease.Aging cell · 2003Article
- Glutamate and amyloid beta-protein rapidly inhibit fast axonal transport in cultured rat hippocampal neurons by different mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- The role of the cytoskeleton in the life cycle of viruses and intracellular bacteria: tracks, motors, and polymerization machines.Current drug targets. Infectious disorders · 2002Article
- Retrograde axonal transport of herpes simplex virus: evidence for a single mechanism and a role for tegument.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Squid axoplasm supports the retrograde axonal transport of herpes simplex virus.The Biological bulletin · 1999Article
- Slow transport of unpolymerized tubulin and polymerized neurofilament in the squid giant axon.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Axoplasmic organelles move on actin as well as microtubules in vitro and axons contain a large amount of actin, but little is known about the organization and distribution of actin filaments within the axon. Here we undertake to define the relationship of the microtubule bundles typically found in axons to actin filaments by applying three microscopic techniques: laser-scanning confocal microscopy of immuno-labeled squid axoplasm; electronmicroscopy of conventionally prepared thin sections; and electronmicroscopy of touch preparations-a thin layer of axoplasm transferred to a specimen grid and negatively stained. Light microscopy shows that longitudinal actin filaments are abundant and usually coincide with longitudinal microtubule bundles. Electron microscopy shows that microfilaments are interwoven with the longitudinal bundles of microtubules. These bundles maintain their integrity when neurofilaments are extracted. Some, though not all microfilaments decorate with the S1 fragment of myosin, and some also act as nucleation sites for polymerization of exogenous actin, and hence are definitively identified as actin filaments. These actin filaments range in minimum length from 0.5 to 1.5 microm with some at least as long as 3.5 microm. We conclude that the microtubule-based tracks for fast organelle transport also include actin filaments. These actin filaments are sufficiently long and abundant to be ancillary or supportive of fast transport along microtubules within bundles, or to extend transport outside of the bundle. These actin filaments could also be essential for maintaining the structural integrity of the microtubule bundles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.