ArticleThe Plant cell1999
Linker histones play a role in male meiosis and the development of pollen grains in tobacco.
Article in The Plant cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 65 citations in OpenAlex.
- Genetic Regulation of Mitosis-Meiosis Fate Decision in Plants: Is Callose an Oversighted Polysaccharide in These Processes?Plants (Basel, Switzerland) · 2023Review
- Genome-wide characterization and evolutionary analysis of linker histones in castor bean (Frontiers in plant science · 2022Article
- Role of H1 linker histones in mammalian development and stem cell differentiation.Biochimica et biophysica acta · 2016Review
- Chromatin dynamics in pollen mother cells underpin a common scenario at the somatic-to-reproductive fate transition of both the male and female lineages in Arabidopsis.Frontiers in plant science · 2015Article
- Overexpression of Camellia sinensis H1 histone gene confers abiotic stress tolerance in transgenic tobacco.Plant cell reports · 2014Article
- Open and closed: the roles of linker histones in plants and animals.Molecular plant · 2014Article
- Article
- The linker histone plays a dual role during gametogenesis in Saccharomyces cerevisiae.Molecular and cellular biology · 2012Article
- Novel roles of Caenorhabditis elegans heterochromatin protein HP1 and linker histone in the regulation of innate immune gene expression.Molecular and cellular biology · 2012Article
- Meiosis-specific loading of the centromere-specific histone CENH3 in Arabidopsis thaliana.PLoS genetics · 2011Article
- Onset of grain filling is associated with a change in properties of linker histone variants in maize kernels.Planta · 2010Article
- Histone modifications and chromatin dynamics: a focus on filamentous fungi.FEMS microbiology reviews · 2008Review
- Epigenetics and its implications for plant biology. 1. The epigenetic network in plants.Annals of botany · 2005Review
- Suppression of histone H1 genes in Arabidopsis results in heritable developmental defects and stochastic changes in DNA methylation.Genetics · 2005Article
- Evolution of the regular zone of histone H1 in fabaceae plants.Journal of molecular evolution · 2004Article
- H1 linker histones are essential for mouse development and affect nucleosome spacing in vivo.Molecular and cellular biology · 2003Article
- Histone H1 Is required for proper regulation of pyruvate decarboxylase gene expression in Neurospora crassa.Eukaryotic cell · 2003Article
- Phosphorylation and an ATP-dependent process increase the dynamic exchange of H1 in chromatin.The Journal of cell biology · 2002Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To examine the function of linker histone variants, we produced transgenic tobacco plants in which major somatic histone variants H1A and H1B were present at approximately 25% of their usual amounts in tobacco chromatin. The decrease in these major variants was accompanied by a compensatory increase in the four minor variants, namely, H1C to H1F. These minor variants are smaller and less highly charged than the major variants. This change offered a unique opportunity to examine the consequences to a plant of major remodeling of its chromatin set of linker histones. Plants with markedly altered proportions of H1 variants retained normal nucleosome spacing, but their chromosomes were less tightly packed than those of control plants. The transgenic plants grew normally but showed characteristic aberrations in flower development and were almost completely male sterile. These features correlated with changes in the temporal but not the spatial pattern of expression of developmental genes that could be linked to the abnormal flower phenotypes. Preceding these changes in flower morphology were strong aberrations in male gametogenesis. The earliest symptoms may have resulted from disturbances in correct pairing or segregation of homologous chromosomes during meiosis. No aberrations were observed during mitosis. We conclude that in plants, the physiological stoichiometry and distribution of linker histone variants are crucial for directing male meiosis and the subsequent development of functional pollen grains.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.