ArticleJournal of virology2000
MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Article
- Heterozygous and generalist MxA super-restrictors overcome breadth-specificity trade-offs in antiviral restriction.Science advances · 2025Article
- The Role of Nucleocapsid Protein (NP) in the Immunology of Crimean-Congo Hemorrhagic Fever Virus (CCHFV).Viruses · 2024Review
- Functional Roles of Pattern Recognition Receptors That Recognize Virus Nucleic Acids in Human Adipose-Derived Mesenchymal Stem Cells.BioMed research international · 2016Article
- p204-Mediated innate antiviral responses in mouse adipose cells and their effects on cell functions.Immunology and cell biology · 2015Article
- Mx proteins: antiviral gatekeepers that restrain the uninvited.Microbiology and molecular biology reviews : MMBR · 2013Review
- Partial antiviral activities detection of chicken Mx jointing with neuraminidase gene (NA) against Newcastle disease virus.PloS one · 2013Article
- Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA.Cell host & microbe · 2012Article
- The viral nucleoprotein determines Mx sensitivity of influenza A viruses.Journal of virology · 2011Article
- RNA aptamers directed to human immunodeficiency virus type 1 Gag polyprotein bind to the matrix and nucleocapsid domains and inhibit virus production.Journal of virology · 2011Article
- The cytoplasmic location of chicken mx is not the determining factor for its lack of antiviral activity.PloS one · 2010Article
- Asparagine 631 variants of the chicken Mx protein do not inhibit influenza virus replication in primary chicken embryo fibroblasts or in vitro surrogate assays.Journal of virology · 2008Article
- Influenza A virus strains differ in sensitivity to the antiviral action of Mx-GTPase.Journal of virology · 2008Article
- Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling.Journal of virology · 2007Article
- Negative regulation of the alpha interferon-induced antiviral response by the Ras/Raf/MEK pathway.Journal of virology · 2006Article
- Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome.Nucleic acids research · 2004Article
- Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Antiviral actions of interferons.Clinical microbiology reviews · 2001Review
- Thogoto virus matrix protein is encoded by a spliced mRNA.Journal of virology · 2000Article
- A monomeric GTPase-negative MxA mutant with antiviral activity.Journal of virology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human MxA protein accumulates in the cytoplasm of interferon-treated cells and inhibits the multiplication of several RNA viruses, including Thogoto virus (THOV), a tick-borne orthomyxovirus that transcribes and replicates its genome in the cell nucleus. The antiviral mechanism of MxA was investigated by using two alternative minireplicon systems in which recombinant viral ribonucleoprotein complexes (vRNPs) of THOV were reconstituted from cloned cDNAs. A chloramphenicol acetyltransferase reporter minigenome RNA was expressed either by T7 RNA polymerase in the cytoplasm of transfected cells or, alternatively, by RNA polymerase I in the nucleus. The inhibitory effect of MxA was studied in both cellular compartments by coexpressing wild-type MxA or TMxA, an artificial nuclear form of MxA. Our results indicate that both MxA proteins recognize the assembled vRNP rather than the newly synthesized unassembled components. The present findings are consistent with previous data which indicated that cytoplasmic MxA prevents transport of vRNPs into the nucleus, whereas nuclear MxA directly inhibits the viral polymerase activity in the nucleus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.