ArticleJournal of virology2000
Immune complexes containing human immunodeficiency virus type 1 primary isolates bind to lymphoid tissue B lymphocytes and are infectious for T lymphocytes.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 64 citations in OpenAlex.
- Antigen Presenting Cell-Mediated HIV-1Medical research archives · 2023Article
- In the Crosshairs: RNA Viruses OR Complement?Frontiers in immunology · 2020Review
- Complement Evasion Strategies of Viruses: An Overview.Frontiers in microbiology · 2017Review
- HIV-associated memory B cell perturbations.Vaccine · 2015Review
- Review
- Antibodies attenuate the capacity of dendritic cells to stimulate HIV-specific cytotoxic T lymphocytes.The Journal of allergy and clinical immunology · 2012Article
- Direct phenotypical and functional dysregulation of primary human B cells by human immunodeficiency virus (HIV) type 1 in vitro.PloS one · 2012Article
- The role of innate APOBEC3G and adaptive AID immune responses in HLA-HIV/SIV immunized SHIV infected macaques.PloS one · 2012Article
- Dynamic antibody specificities and virion concentrations in circulating immune complexes in acute to chronic HIV-1 infection.Journal of virology · 2011Article
- The good and evil of complement activation in HIV-1 infection.Cellular & molecular immunology · 2010Review
- HIV reservoirs in vivo and new strategies for possible eradication of HIV from the reservoir sites.HIV/AIDS (Auckland, N.Z.) · 2010Article
- Article
- DC-SIGN on B lymphocytes is required for transmission of HIV-1 to T lymphocytes.PLoS pathogens · 2006Article
- Simian immunodeficiency virus (SIV)/immunoglobulin G immune complexes in SIV-infected macaques block detection of CD16 but not cytolytic activity of natural killer cells.Clinical and vaccine immunology : CVI · 2006Article
- Chimeric SCID-hu Model as a Human Hematopoietic Stem Cell Host That Recapitulates the Effects of HIV-1 on Bone Marrow Progenitors in Infected Patients.Journal of stem cells · 2006Article
- Interaction of immune complexes isolated from hepatitis C virus-infected individuals with human cell lines.Medical microbiology and immunology · 2005Article
- Human immunodeficiency virus type 1 bound to B cells: relationship to virus replicating in CD4+ T cells and circulating in plasma.Journal of virology · 2002Article
- DC-SIGN interactions with human immunodeficiency virus: virus binding and transfer are dissociable functions.Journal of virology · 2001Article
- B cells of HIV-1-infected patients bind virions through CD21-complement interactions and transmit infectious virus to activated T cells.The Journal of experimental medicine · 2000Article
- CD4-Negative cells bind human immunodeficiency virus type 1 and efficiently transfer virus to T cells.Journal of virology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
This study investigated the interaction of tonsil B lymphocytes with immune complexes containing human immunodeficiency virus (HIV IC) primary isolates and the infectivity of the B cell-bound HIV IC. Treatment of virus with a source of antibody and complement increased HIV IC binding to B cells by 5.6-fold. Most of the HIV IC that bound to B cells were not internalized but remained on the cell surface and were gradually released over 72 h. Cell-bound HIV IC were highly infectious for T cells while virus released by cultured B cells was only slightly infectious. Removal of HIV IC from the B-cell surface by protease treatment reduced the infection of T cells to near-background levels, indicating that infectious virus remained on the B-cell surface. These studies show that B lymphocytes can carry and transfer infectious HIV IC to T cells and thus suggest a novel mode of infection of T cells in lymphoid tissue that could be important for pathogenesis during HIV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.