ArticleProceedings of the National Academy of Sciences of the United States of America1999
Identification of an early T cell progenitor for a pathway of T cell maturation in the bone marrow.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Identification of a novel lymphoid population in the murine epidermis.Scientific reports · 2015Article
- Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- In vivo fate mapping identifies pre-TCRα expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis.The Journal of experimental medicine · 2013Article
- Article
- Signal integration and crosstalk during thymocyte migration and emigration.Nature reviews. Immunology · 2011Review
- Differences in Bcl-2 expression by T-cell subsets alter their balance after in vivo irradiation to favor CD4+Bcl-2hi NKT cells.European journal of immunology · 2009Article
- Article
- Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation.Blood · 2006Article
- T lymphoid differentiation in human bone marrow.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have identified a rare ( approximately 0.05-0.1%) population of cells (Thy-1(hi)CD16(+)CD44(hi)CD2(-)TCRalphabeta(-)B220(-)M ac-1(-)NK1. 1(-)) in the adult mouse bone marrow that generates CD4(+) and CD8(+) TCRalphabeta(+) T cells after tissue culture for 48 hr in the presence of Ly5 congenic marrow cells. The essential stages in the maturation of the progenitors were determined; the stages included an early transition from CD2(-)CD16(+)CD44(hi)TCRalphabeta(-) to CD2(+)CD16(int/-)CD44(int/-)TCRalphabeta(-) cells, and a later transition to CD4(+)CD8(+)TCRalphabeta(+) double-positive T cells that rapidly generate the CD4(+) and CD8(+) single-positive T cells. The maturation of the progenitors is almost completely arrested at the CD2(+)TCRalphabeta(-) stage by the presence of mature T cells at the initiation of cultures. This alternate pathway is supported by the marrow microenvironment; it recapitulates critical intermediary steps in intrathymic T cell maturation.
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Registered trials
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