ArticleProceedings of the National Academy of Sciences of the United States of America1999
Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- B-1 derived anti-Thy-1 B cells in old aged mice develop lymphoma/leukemia with high expression of CD11b and Hamp2 that different from TCL1 transgenic mice.Immunity & ageing : I & A · 2024Article
- Activity and Function in Human Cells of the Evolutionary Conserved Exonuclease Polynucleotide Phosphorylase.International journal of molecular sciences · 2022Review
- Review
- The TCL1 function revisited focusing on metabolic requirements of stemness.Cell cycle (Georgetown, Tex.) · 2019Review
- A Role for KLF4 in Promoting the Metabolic Shift via TCL1 during Induced Pluripotent Stem Cell Generation.Stem cell reports · 2017Article
- Protooncogene TCL1b functions as an Akt kinase co-activator that exhibits oncogenic potency in vivo.Oncogenesis · 2013Article
- Article
- Article
- Detection of Epstein-Barr virus in T-cell prolymphocytic leukemia cells in vitro.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2008Article
- Article
- MicroRNAs and genomic instability.Seminars in cancer biology · 2007Review
- Regulation of the Akt kinase by interacting proteins.Oncogene · 2005Review
- Identification, characterization and metagenome analysis of oocyte-specific genes organized in clusters in the mouse genome.BMC genomics · 2005Article
- Molecular cytogenetic detection of chromosomal breakpoints in T-cell receptor gene loci.Leukemia · 2003Article
- TCL1 participates in early embryonic development and is overexpressed in human seminomas.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The role of TCL1 in human T-cell leukemia.Oncogene · 2001Review
- Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia.Oncogene · 2000Article
- Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
TCL1 and TCL1b genes on human chromosome 14q23.1 are activated in T cell leukemias by translocations and inversions at 14q32.1, juxtaposing them to regulatory elements of T cell receptor genes. In this report we present the cloning, mapping, and expression analysis of the human and murine TCL1/Tcl1 locus. In addition to TCL1 and TCL1b, the human locus contains two additional genes, TCL1-neighboring genes (TNG) 1 and 2, encoding proteins of 141 and 110 aa, respectively. Both genes show no homology to any known genes, but their expression profiles are very similar to those of TCL1 and TCL1b. TNG1 and TNG2 also are activated in T cell leukemias with rearrangements at 14q32.1. To aid in the development of a mouse model we also have characterized the murine Tcl1 locus and found five genes homologous to human TCL1b. Tcl1b1-Tcl1b5 proteins range from 117 to 123 aa and are 65-80% similar, but they show only a 30-40% similarity to human TCL1b. All five mouse Tcl1b and murine Tcl1 mRNAs are abundant in mouse oocytes and two-cell embryos but rare in various adult tissues and lymphoid cell lines. These data suggest a similar or complementary function of these proteins in early embryogenesis.
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