ArticleProceedings of the National Academy of Sciences of the United States of America1999
Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.
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Who cites it
101 citing papers in PubMed, 233 citations in OpenAlex.
- KAT6A is essential for developmental control gene expression in neural stem and progenitor cells.PLoS genetics · 2026Article
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- trithorax is an essential regulator of cardiac Hox gene expression and anterior-posterior patterning of the Drosophila embryonic heart tube.Biology open · 2025Article
- Review
- Regulation of developmental hierarchy inScience advances · 2022Article
- Bistable Photoswitch Allows in Vivo Control of Hematopoiesis.ACS central science · 2022Article
- Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia.eLife · 2021Article
- Loss of histone methyltransferase ASH1L in the developing mouse brain causes autistic-like behaviors.Communications biology · 2021Article
- COMPASS and SWI/SNF complexes in development and disease.Nature reviews. Genetics · 2021Review
- Identification of Jmjd3 as an Essential Epigenetic Regulator ofFrontiers in cell and developmental biology · 2021Article
- HOXA5 Expression Is Elevated in Breast Cancer and Is Transcriptionally Regulated by Estradiol.Frontiers in genetics · 2020Article
- The Chromatin-Remodeling Factor PICKLE Antagonizes Polycomb Repression ofPlant physiology · 2019Article
- Why are so many MLL lysine methyltransferases required for normal mammalian development?Cellular and molecular life sciences : CMLS · 2019Review
- Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins.Clinical epigenetics · 2018Review
- Evolutionary changes of Hox genes and relevant regulatory factors provide novel insights into mammalian morphological modifications.Integrative zoology · 2018Article
- Low HOX gene expression in PML-RARα-positive leukemia results from suppressed histone demethylation.Epigenetics · 2018Article
- Article
- Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin.Oncotarget · 2017Article
- Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia.Nature medicine · 2017Article
- Article
41 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Control of cell identity during development is specified in large part by the unique expression patterns of multiple homeobox-containing (Hox) genes in specific segments of an embryo. Trithorax and Polycomb-group (Trx-G and Pc-G) proteins in Drosophila maintain Hox expression or repression, respectively. Mixed lineage leukemia (MLL) is frequently involved in chromosomal translocations associated with acute leukemia and is the one established mammalian homologue of Trx. Bmi-1 was first identified as a collaborator in c-myc-induced murine lymphomagenesis and is homologous to the Drosophila Pc-G member Posterior sex combs. Here, we note the axial-skeletal transformations and altered Hox expression patterns of Mll-deficient and Bmi-1-deficient mice were normalized when both Mll and Bmi-1 were deleted, demonstrating their antagonistic role in determining segmental identity. Embryonic fibroblasts from Mll-deficient compared with Bmi-1-deficient mice demonstrate reciprocal regulation of Hox genes as well as an integrated Hoxc8-lacZ reporter construct. Reexpression of MLL was able to overcome repression, rescuing expression of Hoxc8-lacZ in Mll-deficient cells. Consistent with this, MLL and BMI-I display discrete subnuclear colocalization. Although Drosophila Pc-G and Trx-G members have been shown to maintain a previously established transcriptional pattern, we demonstrate that MLL can also dynamically regulate a target Hox gene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.