ArticleMolecular biology of the cell1999
LvsA, a protein related to the mouse beige protein, is required for cytokinesis in Dictyostelium.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- Dynamin-Like Protein B ofCells · 2019Article
- Rab8a regulates the exocyst-mediated kiss-and-run discharge of the Dictyostelium contractile vacuole.Molecular biology of the cell · 2012Article
- The enlarged lysosomes in beige j cells result from decreased lysosome fission and not increased lysosome fusion.Traffic (Copenhagen, Denmark) · 2012Article
- Regulation of contractile vacuole formation and activity in Dictyostelium.The EMBO journal · 2008Article
- Dictyostelium Aurora kinase has properties of both Aurora A and Aurora B kinases.Eukaryotic cell · 2008Article
- The WD repeat protein FAN regulates lysosome size independent from abnormal downregulation/membrane recruitment of protein kinase C.Experimental cell research · 2007Article
- Copine A is required for cytokinesis, contractile vacuole function, and development in Dictyostelium.Eukaryotic cell · 2007Article
- The contractile vacuole in Ca2+-regulation in Dictyostelium: its essential function for cAMP-induced Ca2+-influx.BMC developmental biology · 2006Article
- Contractile ring-independent localization of DdINCENP, a protein important for spindle stability and cytokinesis.Molecular biology of the cell · 2006Article
- Article
- The identification of pats1, a novel gene locus required for cytokinesis in Dictyostelium discoideum.Molecular biology of the cell · 2003Article
- Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain.The EMBO journal · 2002Article
- Targeted new membrane addition in the cleavage furrow is a late, separate event in cytokinesis.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Dictyostelium LvsB mutants model the lysosomal defects associated with Chediak-Higashi syndrome.Molecular biology of the cell · 2002Article
- Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
We isolated a Dictyostelium cytokinesis mutant with a defect in a novel locus called large volume sphere A (lvsA). lvsA mutants exhibit an unusual phenotype when attempting to undergo cytokinesis in suspension culture. Early in cytokinesis, they initiate furrow formation with concomitant myosin II localization at the cleavage furrow. However, the furrow is later disrupted by a bulge that forms in the middle of the cell. This bulge is bounded by furrows on both sides, which are often enriched in myosin II. The bulge can increase and decrease in size multiple times as the cell attempts to divide. Interestingly, this phenotype is similar to the cytokinesis failure of Dictyostelium clathrin heavy-chain mutants. Furthermore, both cell lines cap ConA receptors but form only a C-shaped loose cap. Unlike clathrin mutants, lvsA mutants are not defective in endocytosis or development. The LvsA protein shares several domains in common with the molecules beige and Chediak-Higashi syndrome proteins that are important for lysosomal membrane traffic. Thus, on the basis of the sequence analysis of the LvsA protein and the phenotype of the lvsA mutants, we postulate that LvsA plays an important role in a membrane-processing pathway that is essential for cytokinesis.
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