ArticleThe Journal of experimental medicine1999
High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 84 citations in OpenAlex.
- Involvement of Virus-Induced Interferon Production in IgG Autoantibody-Mediated Anemia.International journal of molecular sciences · 2021Article
- Enhancement of the blood-circulation time and performance of nanomedicines via the forced clearance of erythrocytes.Nature biomedical engineering · 2020Article
- Characterization of the human myelin oligodendrocyte glycoprotein antibody response in demyelination.Acta neuropathologica communications · 2019Article
- Article
- Autoantibodies in SLE: Specificities, Isotypes and Receptors.Antibodies (Basel, Switzerland) · 2016Review
- Fc receptors as adaptive immunoreceptors.Current topics in microbiology and immunology · 2014Review
- O-glycosylated IgA rheumatoid factor induces IgA deposits and glomerulonephritis.Journal of the American Society of Nephrology : JASN · 2012Article
- Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia.Nature medicine · 2011Article
- Hemophagocytosis causes a consumptive anemia of inflammation.The Journal of experimental medicine · 2011Article
- A flow cytometry-based strategy to identify and express IgM from VH1-69+ clonal peripheral B cells.Journal of immunological methods · 2011Article
- Role of Gas6 in erythropoiesis and anemia in mice.The Journal of clinical investigation · 2008Article
- Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein.Nature medicine · 2007Article
- Fcgamma receptor-dependent effector mechanisms regulate CD19 and CD20 antibody immunotherapies for B lymphocyte malignancies and autoimmunity.Springer seminars in immunopathology · 2006Article
- Molecular and cellular basis for pathogenicity of autoantibodies: lessons from murine monoclonal autoantibodies.Springer seminars in immunopathology · 2006Review
- Article
- Enhancement of autoantibody pathogenicity by viral infections in mouse models of anemia and thrombocytopenia.Autoimmunity reviews · 2005Review
- Multiple loci are linked with anti-red blood cell antibody production in NZB mice -- comparison with other phenotypes implies complex modes of action.Clinical and experimental immunology · 2004Article
- The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy.The Journal of experimental medicine · 2004Article
- Article
- Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody.The Journal of experimental medicine · 2002Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To assess the potency of low-affinity anti-red blood cell (RBC) autoantibodies in the induction of anemia, we generated an immunoglobulin (Ig)G2a class-switch variant of a 4C8 IgM anti-mouse RBC autoantibody, and compared its pathogenic potential with that of its IgM isotype and a high-affinity 34-3C IgG2a autoantibody. The RBC-binding activity of the 4C8 IgG2a variant was barely detectable, at least 1,000 times lower than that of its IgM isotype, having a high-binding avidity, and that of the 34-3C IgG2a monoclonal antibody (mAb). This low-affinity feature of the 4C8 mAb was consistent with the lack of detection of opsonized RBCs in the circulating blood from the 4C8 IgG2a-injected mice. However, the 4C8 IgG2a variant was highly pathogenic, as potent as its IgM isotype and the 34-3C IgG2a mAb, due to its capacity to interact with Fc receptors involved in erythrophagocytosis. In addition, our results indicated that the pentameric form of the low-affinity IgM isotype, by promoting the binding and agglutination of RBCs, is critical for its pathogenic activity. Demonstration of the remarkably high pathogenic potency of low-affinity autoantibodies, if combined with appropriate heavy chain effector functions, highlights the critical role of the Ig heavy chain constant regions, but the relatively minor role of autoantigen-binding affinities, in autoimmune hemolytic anemia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.