ReviewNature1999
The alliance of genes and environment in asthma and allergy.
Review in Nature, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 5 syntheses or guidelines pooled it, 366 citations in OpenAlex.
- Interleukin-13 gene polymorphisms and asthma susceptibility in children: a meta-analysis.BMC pediatrics · 2025Pooled it
- Hypertensive disorders in pregnancy and risk of asthma in offspring: a systematic review and meta-analysis.BMJ open · 2021Pooled it
- Association of β2-adrenergic receptor gene polymorphisms (rs1042713, rs1042714, rs1042711) with asthma risk: a systematic review and updated meta-analysis.BMC pulmonary medicine · 2019Pooled it
- Pooled-analysis of the association between TIM-1 5383_5397 insertion/deletion polymorphism and asthma susceptibility.Molecular biology reports · 2014Pooled it
- Association between tumor necrosis factor-α rs1800629 polymorphism and risk of asthma: a meta-analysis.PloS one · 2014Pooled it
- Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects.Biomedicines · 2022Review
- Vertical Transfer of Metabolites Detectable from Newborn's Dried Blood Spot Samples Using UPLC-MS: A Chemometric Study.Metabolites · 2022Article
- Hypertensive disorders of pregnancy and risk of asthma in offspring: protocol for a systematic review and meta-analysis.BMJ open · 2020Article
- Asthma Control and Its Predictive Factors in Adult Asthma Patients.Journal of clinical medicine research · 2019Article
- BAL Cell Gene Expression in Severe Asthma Reveals Mechanisms of Severe Disease and Influences of Medications.American journal of respiratory and critical care medicine · 2019Article
- Correlation between IL-4 and IL-13 gene polymorphisms and asthma in Uygur children in Xinjiang.Experimental and therapeutic medicine · 2019Article
- Article
- Association of interleukin-17a rs2275913 gene polymorphism and asthma risk: a meta-analysis.Archives of medical science : AMS · 2018Review
- AllerGAtlas 1.0: a human allergy-related genes database.Database : the journal of biological databases and curation · 2018Article
- Epidemiology of allergic rhinitis and associated risk factors in Asia.The World Allergy Organization journal · 2018Review
- Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach.Clinical epigenetics · 2018Article
- Targeting the PGDDrugs · 2017Review
- In Utero exposure to genistein enhanced intranasal house dust mite allergen-induced respiratory sensitization in young adult B6C3F1 mice.Toxicology letters · 2016Article
- Association between IL-17F rs763780 polymorphism and susceptibility of asthma: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Innate lymphoid cells and cytokines of the novel subtypes of helper T cells in asthma.Asia Pacific allergy · 2014Article
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The diseases of asthma, eczema and hay fever are typified by reactions to common allergens, which are mediated by immunoglobulin E. These allergic diseases are increasing in prevalence, and are now a major source of disability throughout the developed world. They are the result of complex interactions between largely unknown genetic and environmental mechanisms. The identification of the environmental factors offers the real possibility of prevention of disease, and unravelling the genetics of allergic illnesses is likely to change their classification and treatment. Early life seems particularly important, when the initiation of allergic disease may result from genetic and environmental modification of the immune interaction between mother and child.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.