ReviewJournal of psychiatry & neuroscience : JPN1999
The prediction and prevention of Alzheimer's disease--towards a research agenda.
Review in Journal of psychiatry & neuroscience : JPN, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease.The Cochrane database of systematic reviews · 2012Pooled it
- Differences in olfactory functional connectivity in early-onset depression and late-onset depression.Psychoradiology · 2023Article
- Effect of sex and age on traumatic brain injury: a geographical comparative study.Archives of public health = Archives belges de sante publique · 2017Article
- Anti-RAGE and Abeta immunoglobulin levels are related to dementia level and cognitive performance.The journals of gerontology. Series A, Biological sciences and medical sciences · 2009Article
- Is dementia preventable?Dialogues in clinical neuroscience · 2009Article
- Neuropsychological prediction of conversion to dementia from questionable dementia: statistically significant but not yet clinically useful.Journal of neurology, neurosurgery, and psychiatry · 2003Article
- The Alzheimer's disease cooperative study prevention instrument project: longitudinal outcome of behavioral measures as predictors of cognitive decline.Dementia and geriatric cognitive disorders extraArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper sets a research agenda for the prediction and prevention of future onset of Alzheimer's disease (AD). From a MEDLINE review of the literature, the authors found age to be a predictor of AD. The literature also indicates that memory and attentional impairments predict AD, although the relative risk is relatively low. Late-onset depression may also predict AD, but these data are limited by a lack of cohort studies. Studying cognitively impaired subjects with late-onset depression may identify a high-risk group, facilitating prevention trials. Characteristics of an "ideal" preventive agent are suggested. There is a biologic rationale, and preliminary evidence, that non-steroidal anti-inflammatory drugs (including ASA), estrogen and vitamin E may play a preventive role in AD. Other compounds (such as acetylcholinesterase inhibitors) are also promising, but costs, side effects, and lack of other health benefits may preclude their use in all but very high-risk groups.
Indexed as
Identifiers
10586533PMC1189056W65229365What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.