ArticleBiophysical journal1999
A model for membrane patchiness: lateral diffusion in the presence of barriers and vesicle traffic.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 76 citations in OpenAlex.
- A Rationale for Mesoscopic Domain Formation in Biomembranes.Biomolecules · 2018Article
- Membrane Diffusion Occurs by Continuous-Time Random Walk Sustained by Vesicular Trafficking.Biophysical journal · 2018Article
- The Life of a Membrane Protein.Biophysical journal · 2018Article
- Dynamics of the actin cytoskeleton mediates receptor cross talk: An emerging concept in tuning receptor signaling.The Journal of cell biology · 2016Review
- Sphingolipid Organization in the Plasma Membrane and the Mechanisms That Influence It.Frontiers in cell and developmental biology · 2016Review
- Organizing MHC Class II Presentation.Frontiers in immunology · 2014Review
- Sphingolipid domains in the plasma membranes of fibroblasts are not enriched with cholesterol.The Journal of biological chemistry · 2013Article
- Lifetime of major histocompatibility complex class-I membrane clusters is controlled by the actin cytoskeleton.Biophysical journal · 2012Article
- Class I MHC molecules as probes of membrane patchiness: from biophysical measurements to modulation of immune responses.Immunologic research · 2010Review
- Morphology and interaction between lipid domains.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Diffusion in a fluid membrane with a flexible cortical cytoskeleton.Biophysical journal · 2009Article
- An introduction to critical points for biophysicists; observations of compositional heterogeneity in lipid membranes.Biochimica et biophysica acta · 2009Review
- Zygotically controlled F-actin establishes cortical compartments to stabilize furrows during Drosophila cellularization.Journal of cell science · 2008Article
- Domain formation in membranes caused by lipid wetting of protein.Physical review. E, Statistical, nonlinear, and soft matter physics · 2008Article
- Microscopic simulation of membrane molecule diffusion on corralled membrane surfaces.Biophysical journal · 2008Article
- Dynamic patches of membrane proteins.Biophysical journal · 2007Article
- Dynamics in the plasma membrane: how to combine fluidity and order.The EMBO journal · 2006Review
- Clustering class I MHC modulates sensitivity of T cell recognition.Journal of immunology (Baltimore, Md. : 1950) · 2006Article
- Regulation and organization of adenylyl cyclases and cAMP.The Biochemical journal · 2003Review
- Dynamic, yet structured: The cell membrane three decades after the Singer-Nicolson model.Proceedings of the National Academy of Sciences of the United States of America · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Patches (lateral heterogeneities) of cell surface membrane proteins and lipids have been imaged by a number of different microscopy techniques. This patchiness has been taken as evidence for the organization of membranes into domains whose composition differs from the average for the entire membrane. However, the mechanism and specificity of patch formation are not understood. Here we show how vesicle traffic to and from a cell surface membrane can create patches of molecules of the size observed experimentally. Our computer model takes into account lateral diffusion, barriers to lateral diffusion, and vesicle traffic to and from the plasma membrane. Neither barriers nor vesicle traffic alone create and maintain patches. Only the combination of these produces a dynamic but persistent patchiness of membrane proteins and lipids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.