ArticleBritish journal of cancer1999
Chromosome alterations and E-cadherin gene mutations in human lobular breast cancer.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 102 citations in OpenAlex.
- CDH1 Genotype Exploration in Women With Hereditary Lobular Breast Cancer Phenotype.JAMA network open · 2024Article
- The Potential Role of CDH1 as an Oncogene Combined With Related miRNAs and Their Diagnostic Value in Breast Cancer.Frontiers in endocrinology · 2022Article
- Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook.Frontiers in endocrinology · 2022Review
- Phylogenetic analysis of combined lobular and ductal carcinoma of the breast.Molecular medicine reports · 2021Article
- Lobular Breast Cancer: Histomorphology and Different Concepts of a Special Spectrum of Tumors.Cancers · 2021Review
- Aberrations of Chromosomes 1 and 16 in Breast Cancer: A Framework for Cooperation of Transcriptionally Dysregulated Genes.Cancers · 2021Article
- E-cadherin deregulation in breast cancer.Journal of cellular and molecular medicine · 2020Review
- The molecular mechanisms underlying reduced E-cadherin expression in invasive ductal carcinoma of the breast: high throughput analysis of large cohorts.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- Clinicopathological characteristics and survival outcomes in pleomorphic lobular breast carcinoma of the breast: a SEER population-based study.Cancer medicine · 2017Article
- Recognition of and recent issues in hereditary diffuse gastric cancer.Journal of gastroenterology · 2015Review
- E-cadherin and gastric cancer: cause, consequence, and applications.BioMed research international · 2014Review
- Sheep, wolf, or werewolf: cancer stem cells and the epithelial-to-mesenchymal transition.Cancer letters · 2013Review
- Estrogen switches pure mucinous breast cancer to invasive lobular carcinoma with mucinous features.Breast cancer research and treatment · 2013Article
- Prognostic significance of Wnt-1, β-catenin and E-cadherin expression in advanced colorectal carcinoma.Pathology oncology research : POR · 2011Article
- Changes in CpG islands promoter methylation patterns during ductal breast carcinoma progression.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2009Article
- In breast carcinoma dysadherin expression is correlated with invasiveness but not with E-cadherin.British journal of cancer · 2007Article
- Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis.BMC cancer · 2007Article
- Loss of heterozygosity testing using real-time PCR analysis of single nucleotide polymorphisms.Journal of cancer research and clinical oncology · 2006Article
- Relevance of the stroma and epithelial-mesenchymal transition (EMT) for the rheumatic diseases.Arthritis research & therapy · 2006Review
- Aberrant E-cadherin staining patterns in invasive mammary carcinoma.World journal of surgical oncology · 2005Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied a set of 40 human lobular breast cancers for loss of heterozygosity (LOH) at various chromosome locations and for mutations in the coding region plus flanking intron sequences of the E-cadherin gene. We found a high frequency of LOH (100%, 31/31) at 16q21-q22.1. A significantly higher level of LOH was detected in ductal breast tumours at chromosome arms 1p, 3p, 9p, 11q, 13q and 18q compared to lobular breast tumours. Furthermore, we found a significant association between LOH at 16q containing the E-cadherin locus and lobular histological type. Six different somatic mutations were detected in the E-cadherin gene, of which three were insertions, two deletions and one splice site mutation. Mutations were found in combination with LOH of the wild type E-cadherin locus and loss of or reduced E-cadherin expression detected by immunohistochemistry. The mutations described here have not previously been reported. We compared LOH at different chromosome regions with E-cadherin gene mutations and found a significant association between LOH at 13q and E-cadherin gene mutations. A significant association was also detected between LOH at 13q and LOH at 7q and 11q. Moreover, we found a significant association between LOH at 3p and high S phase, LOH at 9p and low ER and PgR content, LOH at 17p and aneuploidy. We conclude that LOH at 16q is the most frequent chromosome alteration and E-cadherin is a typical tumour suppressor gene in lobular breast cancer.
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