ArticleJournal of computer-aided molecular design1999
Visualisation and integration of G protein-coupled receptor related information help the modelling: description and applications of the Viseur program.
Article in Journal of computer-aided molecular design, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Article
- Identification of core amino acids stabilizing rhodopsin.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Prediction of the odorant binding site of olfactory receptor proteins by human-mouse comparisons.Protein science : a publication of the Protein Society · 2004Article
- Building protein diagrams on the web with the residue-based diagram editor RbDe.Nucleic acids research · 2003Article
- GPCRDB information system for G protein-coupled receptors.Nucleic acids research · 2003Article
- tGRAP, the G-protein coupled receptors mutant database.Nucleic acids research · 2002Article
- Collecting and harvesting biological data: the GPCRDB and NucleaRDB information systems.Nucleic acids research · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
G Protein-Coupled Receptors (GPCRs) constitute a superfamily of receptors that forms an important therapeutic target. The number of known GPCR sequences and related information increases rapidly. For these reasons, we are developing the Viseur program to integrate the available information related to GPCRs. The Viseur program allows one to interactively visualise and/or modify the sequences, transmembrane areas, alignments, models and results of mutagenesis experiments in an integrated environment. This integration increases the ease of modelling GPCRs: visualisation and manipulation improvements enable easier databank interrogation and interpretation. Unique program features include: (i) automatic construction of 'Snake-like' diagrams or hyperlinked GPCR molecular models to HTML or VRML and (ii) automatic access to a mutagenesis data server through the Internet. The novel algorithms or methods involved are presented, followed by the overall complementary features of the program. Finally, we present two applications of the program: (i) an automatic construction of GPCR snake-like diagrams for the GPCRDB WWW server, and (ii) a preparation of the modelling of the 5HT receptor subtypes. The interest of the direct access to mutagenesis results through an alignment and a molecular model are discussed. The Viseur program, which runs on SGI workstations, is freely available and can be used for preparing the modelling of integral membrane proteins or as an alignment editor tool.
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10584220What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.