ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences1999
The proteasome: a macromolecular assembly designed for controlled proteolysis.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Ubiquitin-related gene markers predict immunotherapy response and prognosis in patients with epithelial ovarian carcinoma.Scientific reports · 2024Article
- Cryo-EM of a heterogeneous biochemical fraction elucidates multiple protein complexes from a multicellular thermophilic eukaryote.Journal of structural biology: X · 2023Article
- Review
- Proteotoxicity: A Fatal Consequence of Environmental Pollutants-Induced Impairments in Protein Clearance Machinery.Journal of personalized medicine · 2021Review
- Targeting Mitochondria during Cold Storage to Maintain Proteasome Function and Improve Renal Outcome after Transplantation.International journal of molecular sciences · 2020Review
- Article
- Oncogenic addiction to high 26S proteasome level.Cell death & disease · 2018Article
- Characterization of the Ovarian Tumor Peptidome.Vitamins and hormones · 2018Article
- Comprehensive quantitative analysis of ovarian and breast cancer tumor peptidomes.Journal of proteome research · 2015Article
- An overview of the gene regulatory network controlling trichome development in the model plant, Arabidopsis.Frontiers in plant science · 2014Review
- Comparative informatics analysis to evaluate site-specific protein oxidation in multidimensional LC-MS/MS data.Journal of proteome research · 2013Article
- Proteomic analysis reveals that proteasome subunit beta 6 is involved in hypoxia-induced pulmonary vascular remodeling in rats.PloS one · 2013Article
- Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Peptidomic analysis of human cell lines.Journal of proteome research · 2011Article
- How is the balance between protein synthesis and degradation achieved?Theoretical biology & medical modelling · 2010Article
- The role of the ubiquitin proteasome pathway in keratin intermediate filament protein degradation.Proceedings of the American Thoracic Society · 2010Review
- The ubiquitin-proteasome system in myocardial ischaemia and preconditioning.Cardiovascular research · 2010Review
- A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for huntington disease.Molecular & cellular proteomics : MCP · 2009Article
- Proteasomal protein degradation in Mycobacteria is dependent upon a prokaryotic ubiquitin-like protein.The Journal of biological chemistry · 2009Article
- Crystallization and preliminary X-ray analysis of the Thermoplasma acidophilum 20S proteasome in complex with protein substrates.Acta crystallographica. Section F, Structural biology and crystallization communications · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotic cells, the vast majority of proteins in the cytosol and nucleus are degraded via the proteasome-ubiquitin pathway. The 26S proteasome is a huge protein degradation machine of 2.5 MDa, built of approximately 35 different subunits. It contains a proteolytic core complex, the 20S proteasome and one or two 19S regulatory complexes which associate with the termini of the barrel-shaped 20S core. The 19S regulatory complex serves to recognize ubiquitylated target proteins and is implicated to have a role in their unfolding and translocation into the interior of the 20S complex where they are degraded into oligopeptides. While much progress has been made in recent years in elucidating the structure, assembly and enzymatic mechanism of the 20S complex, our knowledge of the functional organization of the 19S regulator is rather limited. Most of its subunits have been identified, but specific functions can be assigned to only a few of them.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.