Evidence map›Paper›PMID 10581319›Full record

ArticleThe Journal of physiology1999

Mechanisms underlying spontaneous rhythmical contractions in irideal arterioles of the rat.

C E Hill, J Eade, S L Sandow

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In one paragraph

Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 61 citations in OpenAlex.

  1. Article
  2. Synchrony of spontaneous CaJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2020
    Review
  3. Differential effect of calcium-activated potassium and chloride channels on rat basilar artery vasomotion.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014
    Article
  4. Article
  5. Article
  6. Article
  7. An association between vasomotion and oxygen extraction.American journal of physiology. Heart and circulatory physiology · 2011
    Article
  8. Article
  9. Article
  10. Article
  11. Kv1.5 is a major component underlying the A-type potassium current in retinal arteriolar smooth muscle.American journal of physiology. Heart and circulatory physiology · 2007
    Article
  12. Rhythmicity in arterial smooth muscle.The Journal of physiology · 2005
    Review
  13. Review
  14. Article
  15. Article
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  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

C E HillDivision of Neuroscience, John Curtin School of Medical Research, Australian National University, GPO Box 334, Canberra, ACT 2601, Australia. caryl.hill@anu.edu.au
J Eade
S L Sandow
Australian National University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

1. Mechanisms underlying spontaneous rhythmical contractions have been studied in irideal arterioles of the rat using video microscopy and electrophysiology. 2. Rhythmical contractions (4 min-1) were more common during the second and third postnatal weeks and were always preceded by large, slow depolarizations (5-40 mV). 3. Spontaneous contractions were unaffected by tetrodotoxin (1 microM), neurotransmitter receptor antagonists, the sympathetic neurone blocker, guanethidine (5 microM) or sensory neurotoxin, capsaicin (1 microM). 4. Stimulation of sensory nerves inhibited spontaneous activity and this was not prevented by L-NAME (10 microm). 5. L-NAME (10 microm) caused an increase in frequency of spontaneous contractions, while forskolin (30 nM), in the presence of L-NAME, abolished spontaneous, but not nerve-mediated, contractions. 6. Spontaneous activity was not affected by felodipine (1 nM) or nifedipine (1 microM), but was abolished by cadmium chloride (1 microM) or superfusion with calcium-free solution. 7. Caffeine (1 mM), thapsigargin (2 microM) and cyclopiazonic acid (3 microM), but not ryanodine (3 microM), abolished spontaneous and nerve-mediated contractions. After preincubation in L-NAME (10 microM), cyclopiazonic acid abolished spontaneous contractions only. 8. Spontaneous depolarizations and contractions were abolished by 18alpha-glycyrrhetinic acid (20 microM). 9. Results suggest that spontaneous rhythmical contractions are myogenic and result from the cyclical release of calcium from intracellular stores, without a contribution from voltage-dependent calcium channels. Intercellular coupling through gap junctions appears to be essential for co-ordination of these events which could be modulated by nitric oxide and increases in cAMP. The possibility that different intracellular stores underly spontaneous and nerve-mediated contractions is discussed.

Indexed as

Adenosine TriphosphateAge FactorsAnimalsArteriolesCadmium ChlorideCaffeineCalciumCapsaicinCentral Nervous System StimulantsColforsinCyclic AMPDinucleoside PhosphatesEnzyme InhibitorsFelodipineFemaleGap Junctions1229U91Adenosine TriphosphateCadmium ChlorideCaffeineCalciumCapsaicinCentral Nervous System StimulantsColforsinCyclic AMPcytidylyl adenosineDinucleoside PhosphatesEnzyme InhibitorsFelodipineNeuropeptide YNG-Nitroarginine Methyl EsterPeptides, CyclicPlatelet Aggregation InhibitorsPyridoxal Phosphatepyridoxal phosphate-6-azophenyl-2',4'-disulfonic acidRyanodineThapsigarginVasodilator Agents

Identifiers

PMID10581319
PMCPMC2269675
OpenAlexW2141717299

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.