ArticleGenetics1999
Fluxes and metabolic pools as model traits for quantitative genetics. I. The L-shaped distribution of gene effects.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Heterosis Is a Systemic Property Emerging From Non-linear Genotype-Phenotype Relationships: Evidence FromFrontiers in genetics · 2018Article
- Evaluating the transferability of 15 European-derived fasting plasma glucose SNPs in Mexican children and adolescents.Scientific reports · 2016Article
- Genetic basis of metabolome variation in yeast.PLoS genetics · 2014Article
- Linking post-translational modifications and variation of phenotypic traits.Molecular & cellular proteomics : MCP · 2013Article
- A comparative assessment of mandible shape in a consomic strain panel of the house mouse (Mus musculus)--implications for epistasis and evolvability of quantitative traits.BMC evolutionary biology · 2011Article
- Estimating the total number of susceptibility variants underlying complex diseases from genome-wide association studies.PloS one · 2010Article
- Genetic epidemiology of age-related osteoporosis and its clinical applications.Nature reviews. Rheumatology · 2010Review
- Should maize doubled haploids be induced among F(1) or F (2) plants?TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2009Article
- Multilocus epistasis, linkage, and genetic variance in breeding populations with few parents.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2007Article
- Expression genetics and the phenotype revolution.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Review
- Analysis of genotypic variation in fruit flesh total sugar content via an ecophysiological model applied to peach.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2004Article
- What proportion of declared QTL in plants are false?TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2004Article
- Metabolic control analysis as a mechanism that conserves genetic variance during advanced cycle breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2004Article
- A large-sample QTL study in mice: I. Growth.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Genetic variability at neutral markers, quantitative trait land trait in a subdivided population under selection.Genetics · 2003Article
- Article
- Mapping QTLs regulating morpho-physiological traits and yield: case studies, shortcomings and perspectives in drought-stressed maize.Annals of botany · 2002Review
- Nonequivalent Loci and the distribution of mutant effects.Genetics · 2002Article
- Genetic and nongenetic bases for the L-shaped distribution of quantitative trait loci effects.Genetics · 2001Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The fluxes through metabolic pathways can be considered as model quantitative traits, whose QTL are the polymorphic loci controlling the activity or quantity of the enzymes. Relying on metabolic control theory, we investigated the relationships between the variations of enzyme activity along metabolic pathways and the variations of the flux in a population with biallelic QTL. Two kinds of variations were taken into account, the variation of the average enzyme activity across the loci, and the variation of the activity of each enzyme of the pathway among the individuals of the population. We proposed analytical approximations for the flux mean and variance in the population as well as for the additive and dominance variances of the individual QTL. Monte Carlo simulations based on these approximations showed that an L-shaped distribution of the contributions of individual QTL to the flux variance (R(2)) is consistently expected in an F(2) progeny. This result could partly account for the classically observed L-shaped distribution of QTL effects for quantitative traits. The high correlation we found between R(2) value and flux control coefficients variance suggests that such a distribution is an intrinsic property of metabolic pathways due to the summation property of control coefficients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.