ArticleGenetics1999
Cosuppression of I transposon activity in Drosophila by I-containing sense and antisense transgenes.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 61 citations in OpenAlex.
- Article
- Transcriptional and chromatin changes accompanying de novo formation of transgenic piRNA clusters.RNA (New York, N.Y.) · 2018Article
- Natural variation of piRNA expression affects immunity to transposable elements.PLoS genetics · 2017Article
- De novo piRNA cluster formation in the Drosophila germ line triggered by transgenes containing a transcribed transposon fragment.Nucleic acids research · 2013Article
- Codon usage biases of transposable elements and host nuclear genes in Arabidopsis thaliana and Oryza sativa.Genomics, proteomics & bioinformatics · 2009Article
- Endo-siRNAs depend on a new isoform of loquacious and target artificially introduced, high-copy sequences.The EMBO journal · 2009Article
- Epigenetic transmission of piRNAs through the female germline.Genome biology · 2009Review
- Natural epigenetic protection against the I-factor, a Drosophila LINE retrotransposon, by remnants of ancestral invasions.PloS one · 2007Article
- The potential regulation of L1 mobility by RNA interference.Journal of biomedicine & biotechnology · 2006Article
- Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses.Nucleic acids research · 2006Article
- Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogaster genome.Genome biology · 2006Article
- aubergine mutations in Drosophila melanogaster impair P cytotype determination by telomeric P elements inserted in heterochromatin.Molecular genetics and genomics : MGG · 2004Article
- Expression of the telomeric retrotransposon HeT-A in Drosophila melanogaster is correlated with cell proliferation.Development genes and evolution · 2004Article
- Deletion derivatives of the MuDR regulatory transposon of maize encode antisense transcripts but are not dominant-negative regulators of mutator activities.The Plant cell · 2003Article
- Repetitive elements in genomes of parasitic protozoa.Microbiology and molecular biology reviews : MMBR · 2003Review
- Article
- Article
- P-Element repression in Drosophila melanogaster by variegating clusters of P-lacZ-white transgenes.Genetics · 2001Article
- Artificial and epigenetic regulation of the I factor, a nonviral retrotransposon of Drosophila melanogaster.Genetics · 2000Article
- New insights on homology-dependent silencing of I factor activity by transgenes containing ORF1 in Drosophila melanogaster.Genetics · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously shown that the activity of functional I elements introduced into Drosophila devoid of such elements can be repressed by transgenes containing an internal nontranslatable part of the I element itself and that this repressing effect presents features characteristic of homology-dependent gene silencing or cosuppression. Here we show that transgenes containing a fragment of the I element in antisense orientation induce I-element silencing with the same characteristic features as the corresponding sense construct: namely, repression takes several generations to be fully established, with similar rates for sense and antisense constructs, and it is only maternally transmitted, with reversal of the effect through paternal transmission. We also show that transcription of the transgenes is necessary to produce the silencing effect and that repression can be maintained for at least one generation following elimination of the transgenes, thus strongly suggesting that a transgene product and not the transgene per se is the essential intermediate in the silencing effect. The data presented strongly support models in which the repressing effect of antisense transcripts involves the same mechanisms as cosuppression by sense constructs and emphasize the role of symmetrically acting nucleic acid structures in mediating repression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.