ArticleGenetics1999
Analysis of the seven-member AAD gene set demonstrates that genetic redundancy in yeast may be more apparent than real.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 74 citations in OpenAlex.
- Exploring adaptation routes to cold temperatures in the Saccharomyces genus.PLoS genetics · 2025Article
- Functional Divergence in a Multi-gene Family Is a Key Evolutionary Innovation for Anaerobic Growth in Saccharomyces cerevisiae.Molecular biology and evolution · 2022Article
- From Petri Plates to Petri Nets, a revolution in yeast biology.FEMS yeast research · 2022Article
- RNA sequencing reveals metabolic and regulatory changes leading to more robust fermentation performance during short-term adaptation of Saccharomyces cerevisiae to lignocellulosic inhibitors.Biotechnology for biofuels · 2021Article
- Complete genome sequence and analysis of a Saccharomyces cerevisiae strain used for sugarcane spirit production.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- The regulatory control of Cebpa enhancers and silencers in the myeloid and red-blood cell lineages.PloS one · 2019Article
- Whole Genome Sequencing,G3 (Bethesda, Md.) · 2018Article
- Deciphering the Origin, Evolution, and Physiological Function of the Subtelomeric Aryl-Alcohol Dehydrogenase Gene Family in the Yeast Saccharomyces cerevisiae.Applied and environmental microbiology · 2018Article
- Leveraging Genetic-Background Effects in Saccharomyces cerevisiae To Improve Lignocellulosic Hydrolysate Tolerance.Applied and environmental microbiology · 2016Article
- Copy number variations of genes involved in stress responses reflect the redox state and DNA damage in brewing yeasts.Cell stress & chaperones · 2016Article
- Deciphering regulatory variation of THI genes in alcoholic fermentation indicate an impact of Thi3p on PDC1 expression.BMC genomics · 2014Article
- Comparative genomics of emerging pathogens in the Candida glabrata clade.BMC genomics · 2013Article
- Oxidative stress tolerance, adenylate cyclase, and autophagy are key players in the chronological life span of Saccharomyces cerevisiae during winemaking.Applied and environmental microbiology · 2012Article
- Whole-genome comparison reveals novel genetic elements that characterize the genome of industrial strains of Saccharomyces cerevisiae.PLoS genetics · 2011Article
- Microarray analysis of p-anisaldehyde-induced transcriptome of Saccharomyces cerevisiae.Journal of industrial microbiology & biotechnology · 2010Article
- Evaluation of toxicity of the mycotoxin citrinin using yeast ORF DNA microarray and Oligo DNA microarray.BMC genomics · 2007Article
- Plasticity of genetic interactions in metabolic networks of yeast.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Impact of nonsense-mediated mRNA decay on the global expression profile of budding yeast.PLoS genetics · 2006Article
- Genome-wide expression analysis of yeast response during exposure to 4 degrees C.Extremophiles : life under extreme conditions · 2006Article
- Identification of programmed translational -1 frameshifting sites in the genome of Saccharomyces cerevisiae.Genome research · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saccharomyces cerevisiae has seven genes encoding proteins with a high degree (>85%) of amino-acid sequence identity to the aryl-alcohol dehydrogenase of the lignin-degrading, filamentous fungus, Phanerochaete chrysosporium. All but one member of this gene set are telomere associated. Moreover, all contain a sequence similar to the DNA-binding site of the Yap1p transcriptional activator either upstream of or within their coding sequences. The expression of the AAD genes was found to be induced by chemicals, such as diamide and diethyl maleic acid ester (DEME), that cause an oxidative shock by inactivating the glutathione (GSH) reservoir of the cells. In contrast, the oxidizing agent hydrogen peroxide has no effect on the expression of these genes. We found that the response to anti-GSH agents was Yap1p dependent. The very high level of nucleotide sequence similarity between the AAD genes makes it difficult to determine if they are all involved in the oxidative-stress response. The use of single and multiple aad deletants demonstrated that only AAD4 (YDL243c) and AAD6 (YFL056/57c) respond to the oxidative stress. Of these two genes, only AAD4 is likely to be functional since the YFL056/57c open reading frame is interrupted by a stop codon. Thus, in terms of the function in response to oxidative stress, the sevenfold redundancy of the AAD gene set is more apparent than real.
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