ArticleGenes & development1999
The RING finger/B-box factor TAM-1 and a retinoblastoma-like protein LIN-35 modulate context-dependent gene silencing in Caenorhabditis elegans.
Article in Genes & development, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 111 citations in OpenAlex.
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- Harnessing the power of genetics: fast forward genetics in Caenorhabditis elegans.Molecular genetics and genomics : MGG · 2021Review
- A long lost key opens an ancient lock:Biology open · 2020Article
- EzColocalization: An ImageJ plugin for visualizing and measuring colocalization in cells and organisms.Scientific reports · 2018Article
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- Tissue homogeneity requires inhibition of unequal gene silencing during development.The Journal of cell biology · 2016Article
- New genetic regulators question relevance of abundant yolk protein production in C. elegans.Scientific reports · 2015Article
- A complex regulatory network coordinating cell cycles during C. elegans development is revealed by a genome-wide RNAi screen.G3 (Bethesda, Md.) · 2014Article
- BmAly is an important factor in meiotic progression and spermatid differentiation in Bombyx mori (Lepidoptera: Bombycidae).Journal of insect science (Online) · 2014Article
- Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans.Genes & development · 2013Article
- Caenorhabditis elegans histone deacetylase hda-1 is required for morphogenesis of the vulva and LIN-12/Notch-mediated specification of uterine cell fates.G3 (Bethesda, Md.) · 2013Article
- A network of genes antagonistic to the LIN-35 retinoblastoma protein of Caenorhabditis elegans.Genetics · 2012Article
- Mutations in the pqe-1 gene enhance transgene expression in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2012Article
- Expression of a single-copy hsp-16.2 reporter predicts life span.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Article
- Sensory organ remodeling in Caenorhabditis elegans requires the zinc-finger protein ZTF-16.Genetics · 2012Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Context-dependent gene silencing is used by many organisms to stably modulate gene activity for large chromosomal regions. We have used tandem array transgenes as a model substrate in a screen for Caenorhabditis elegans mutants that affect context-dependent gene silencing in somatic tissues. This screen yielded multiple alleles of a previously uncharacterized gene, designated tam-1 (for tandem-array-modifier). Loss-of-function mutations in tam-1 led to a dramatic reduction in the activity of numerous highly repeated transgenes. These effects were apparently context dependent, as nonrepetitive transgenes retained activity in a tam-1 mutant background. In addition to the dramatic alterations in transgene activity, tam-1 mutants showed modest alterations in expression of a subset of endogenous cellular genes. These effects include genetic interactions that place tam-1 into a group called the class B synMuv genes (for a Synthetic Multivulva phenotype); this family plays a negative role in the regulation of RAS pathway activity in C. elegans. Loss-of-function mutants in other members of the class-B synMuv family, including lin-35, which encodes a protein similar to the tumor suppressor Rb, exhibit a hypersilencing in somatic transgenes similar to that of tam-1 mutants. Molecular analysis reveals that tam-1 encodes a broadly expressed nuclear protein with RING finger and B-box motifs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.