ArticleThe Journal of cell biology1999
Morphological control of inositol-1,4,5-trisphosphate-dependent signals.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 57 citations in OpenAlex.
- Biophysical physiology of phosphoinositide rapid dynamics and regulation in living cells.The Journal of general physiology · 2022Article
- Ten steps to investigate a cellular system with mathematical modeling.PLoS computational biology · 2021Article
- Use of virtual cell in studies of cellular dynamics.International review of cell and molecular biology · 2010Review
- Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Initiation and propagation of a neuronal intracellular calcium wave.Journal of computational neuroscience · 2008Article
- Where does all the PIP2 come from?The Journal of physiology · 2007Article
- Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi.Biophysical journal · 2007Article
- Reaction diffusion modeling of calcium dynamics with realistic ER geometry.Biophysical journal · 2006Article
- Models of IP3 and Ca2+ oscillations: frequency encoding and identification of underlying feedbacks.Biophysical journal · 2006Article
- Spines and neurite branches function as geometric attractors that enhance protein kinase C action.The Journal of cell biology · 2005Article
- Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Computational approaches for modeling regulatory cellular networks.Trends in cell biology · 2004Review
- Modeling cell signaling networks.Biology of the cell · 2004Review
- Spatial analysis of 3' phosphoinositide signaling in living fibroblasts: I. Uniform stimulation model and bounds on dimensionless groups.Biophysical journal · 2004Article
- Activation of phospholipase C increases intramembrane electric fields in N1E-115 neuroblastoma cells.Biophysical journal · 2003Article
- Kinetic analysis of receptor-activated phosphoinositide turnover.The Journal of cell biology · 2003Article
- Depolarisation-evoked Ca2+ waves in the non-excitable rat megakaryocyte.The Journal of physiology · 2001Article
- Changes in organization of the endoplasmic reticulum during Xenopus oocyte maturation and activation.Molecular biology of the cell · 2001Article
- Mechanism in the sequential control of cell morphology and S phase entry by epidermal growth factor involves distinct MEK/ERK activations.Molecular biology of the cell · 2001Article
- An image-based model of calcium waves in differentiated neuroblastoma cells.Biophysical journal · 2000Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Inositol-1,4,5-trisphosphate (InsP(3))-mediated calcium signals represent an important mechanism for transmitting external stimuli to the cell. However, information about intracellular spatial patterns of InsP(3) itself is not generally available. In particular, it has not been determined how the interplay of InsP(3) generation, diffusion, and degradation within complex cellular geometries can control the patterns of InsP(3) signaling. Here, we explore the spatial and temporal characteristics of [InsP(3)](cyt) during a bradykinin-induced calcium wave in a neuroblastoma cell. This is achieved by using a unique image-based computer modeling system, Virtual Cell, to integrate experimental data on the rates and spatial distributions of the key molecular components of the process. We conclude that the characteristic calcium dynamics requires rapid, high-amplitude production of [InsP(3)](cyt) in the neurite. This requisite InsP(3) spatiotemporal profile is provided, in turn, as an intrinsic consequence of the cell's morphology, demonstrating how geometry can locally and dramatically intensify cytosolic signals that originate at the plasma membrane. In addition, the model predicts, and experiments confirm, that stimulation of just the neurite, but not the soma or growth cone, is sufficient to generate a calcium response throughout the cell.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.