ArticleBiological psychiatry1999
Qualitative MRI findings in adults with 22q11 deletion syndrome and schizophrenia.
Article in Biological psychiatry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 125 citations in OpenAlex.
- Neurodevelopment in congenital heart disease: a review of antenatal mechanisms and therapeutic potentials.Pediatric research · 2025Review
- Event-related potential (ERP) markers of 22q11.2 deletion syndrome and associated psychosis.Journal of neurodevelopmental disorders · 2023Review
- Heterotopia in Individuals with 22q11.2 Deletion Syndrome.AJNR. American journal of neuroradiology · 2021Article
- Article
- Positive psychotic symptoms are associated with divergent developmental trajectories of hippocampal volume during late adolescence in patients with 22q11DS.Molecular psychiatry · 2020Article
- Assessing auditory processing endophenotypes associated with Schizophrenia in individuals with 22q11.2 deletion syndrome.Translational psychiatry · 2020Article
- Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice.Nature communications · 2020Article
- Placental Pathology and Neuroimaging Correlates in Neonates with Congenital Heart Disease.Scientific reports · 2019Observational
- Diagnostic and therapeutic potential of microRNAs in neuropsychiatric disorders: Past, present, and future.Progress in neuro-psychopharmacology & biological psychiatry · 2017Review
- Polymorphism within a Neuronal Activity-Dependent Enhancer of NgR1 Is Associated with Corpus Callosum Morphology in Humans.Molecular neuropsychiatry · 2015Article
- Investigation of the involvement of MIR185 and its target genes in the development of schizophrenia.Journal of psychiatry & neuroscience : JPN · 2014Article
- Neuroanatomical phenotypes in a mouse model of the 22q11.2 microdeletion.Molecular psychiatry · 2014Article
- Converging levels of analysis on a genomic hotspot for psychosis: insights from 22q11.2 deletion syndrome.Neuropharmacology · 2013Review
- Atlas-based white matter analysis in individuals with velo-cardio-facial syndrome (22q11.2 deletion syndrome) and unaffected siblings.Behavioral and brain functions : BBF · 2012Article
- Cortical gyrification in velo-cardio-facial (22q11.2 deletion) syndrome: a longitudinal study.Schizophrenia research · 2012Article
- Comprehensive neurocognitive endophenotyping strategies for mouse models of genetic disorders.Progress in neurobiology · 2012Review
- The 22q11.2 microdeletion: fifteen years of insights into the genetic and neural complexity of psychiatric disorders.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2011Review
- Association of schizophrenia in 22q11.2 deletion syndrome and gray matter volumetric deficits in the superior temporal gyrus.The American journal of psychiatry · 2011Article
- Regional cortical volumes and congenital heart disease: a MRI study in 22q11.2 deletion syndrome.Journal of neurodevelopmental disorders · 2010Article
- Bridging the gene-behavior divide through neuroimaging deletion syndromes: Velocardiofacial (22q11.2 Deletion) and Williams (7q11.23 Deletion) syndromes.NeuroImage · 2010Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundA genetic syndrome associated with schizophrenia, 22q11 deletion syndrome (22qDS), may represent a genetic subtype of schizophrenia (22qDS-Sz). Structural brain changes are common in schizophrenia and may involve developmental anomalies, but there are no data yet for 22qDS-Sz. The objective of this study was to assess brain structure in adults with 22qDS-Sz using magnetic resonance imaging (MRI).
methodsBrain and arterial MRI scans of 11 adults with 22qDS-Sz (mean age = 28.4 years, SD = 6.5) were systematically assessed by a neuroradiologist for qualitative anomalies.
resultsA high frequency of abnormalities were found: T2 white matter bright foci (BF), 90%; developmental midline anomalies, 45%; cerebral atrophy or ventricular enlargement, 54%; mild cerebellar atrophy, 36%; skull base abnormalities, 55%; and minor vascular abnormalities, 36%.
conclusionsBF and skull base abnormalities, especially in association with neurodevelopmental midline abnormalities, may be distinguishing MRI features for a genetic subtype of schizophrenia involving a deletion on chromosome 22.
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