ArticleAmerican journal of human genetics1999
A general conditional-logistic model for affected-relative-pair linkage studies.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening.Nature genetics · 2015Article
- The fibromyalgia family study: a genome-wide linkage scan study.Arthritis and rheumatism · 2013Article
- Dosage transmission disequilibrium test (dTDT) for linkage and association detection.PloS one · 2013Article
- The null distribution of likelihood-ratio statistics in the conditional-logistic linkage model.Frontiers in genetics · 2013Article
- ASTN1 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2012Article
- A method to detect single-nucleotide polymorphisms accounting for a linkage signal using covariate-based affected relative pair linkage analysis.BMC proceedings · 2011Article
- Some capabilities for model-based and model-free linkage analysis using the program package S.A.G.E. (Statistical Analysis for Genetic Epidemiology).Human heredity · 2011Article
- Linkage analysis in the next-generation sequencing era.Human heredity · 2011Review
- Incorporation of covariates in simultaneous localization of two linked loci using affected relative pairs.BMC genetics · 2010Article
- Genetic linkage of region containing the CREB1 gene to depressive disorders in families with recurrent, early-onset, major depression: a re-analysis and confirmation of sex-specific effect.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Bayesian intervals for linkage locations.Genetic epidemiology · 2009Article
- Finding genes underlying human disease.Clinical genetics · 2009Review
- Design considerations in a sib-pair study of linkage for susceptibility loci in cancer.BMC medical genetics · 2008Article
- Genetic linkage analysis of sarcoidosis phenotypes: the sarcoidosis genetic analysis (SAGA) study.Genes and immunity · 2007Article
- Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates.Molecular psychiatry · 2007Article
- Linkage and association analysis of candidate genes for TB and TNFalpha cytokine expression: evidence for association with IFNGR1, IL-10, and TNF receptor 1 genes.Human genetics · 2007Article
- Adjusting for sex and anti-CCP levels in linkage analysis of rheumatoid arthritis.BMC proceedings · 2007Article
- Comparison of affected sibling-pair linkage methods to identify gene x gene interaction in GAW15 simulated data.BMC proceedings · 2007Article
- A new score statistic to test for association given linkage in affected sibling pair-control designs.BMC proceedings · 2007Article
- Testing genetic linkage with relative pairs and covariates by quasi-likelihood score statistics.Human heredity · 2007Article
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1 author.
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Abstract
Model-free LOD-score methods are often employed to detect linkage between marker loci and common diseases, with samples of affected sib pairs. Although extensions of the basic one-disease-locus model have been proposed that allow separate inclusion of other types of affected relative pairs, discordant relative pairs, covariates, or additional disease loci, a unified framework that can handle all of these features has been lacking. In this report, I propose a conditional-logistic parameterization that generalizes easily to include all of these features. Two data examples, one using simulated data and one using type 1 diabetes, illustrate applications of the models.
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