ArticleDrugs1999
Lactic acidosis in metformin therapy.
Article in Drugs, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Metformin's Role in Hyperlactatemia and Lactic Acidosis in ICU Patients: A Systematic Review.Pharmacology · 2023Pooled it
- Therapeutic Concentrations of Metformin: A Systematic Review.Clinical pharmacokinetics · 2016Pooled it
- Article
- Where Does Metformin Stand in Modern Day Management of Type 2 Diabetes?Pharmaceuticals (Basel, Switzerland) · 2020Review
- The combination of metformin and 2-deoxyglucose significantly inhibits cyst formation in miniature pigs with polycystic kidney disease.British journal of pharmacology · 2019Article
- Metformin-associated lactic acidosis treated successfully by peritoneal dialysis in a resource limited setting: case report.The Pan African medical journal · 2019Article
- Targeting cancer cell metabolism: The combination of metformin and 2-Deoxyglucose regulates apoptosis in ovarian cancer cells via p38 MAPK/JNK signaling pathway.American journal of translational research · 2016Article
- Metformin and cancer: Technical and clinical implications for FDG-PET imaging.World journal of radiology · 2015Article
- Metformin inhibits melanoma development through autophagy and apoptosis mechanisms.Cell death & disease · 2011Article
- The complexities of obesity and diabetes with the development and progression of pancreatic cancer.Biochimica et biophysica acta · 2011Review
- Use of Metformin in Patients with Kidney and Cardiovascular Diseases.Cardiorenal medicine · 2011Article
- Effect of centchroman coadministration on the pharmacokinetics of metformin in rats.Indian journal of pharmacology · 2010Article
- Outcome of severe lactic acidosis associated with metformin accumulation.Critical care (London, England) · 2010Article
- Fatal metformin overdose presenting with progressive hyperglycemia.The western journal of emergency medicine · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The biguanide drugs metformin and phenformin have been linked in the past to lactic acidosis, a metabolic condition associated with high rates of mortality. Although concern over the hyperlactataemic effect of phenformin led to the withdrawal of this drug from clinical practice in the 1970s, the situation with metformin has been less clear. Retrospective data indicate that, in metformin-treated patients with lactic acidosis, neither the degree of hyperlactataemia nor accumulation of metformin is of prognostic significance. Furthermore, the lowest rates of mortality were seen in patients with high plasma concentrations of metformin, which has led to the hypothesis that the drug may confer some benefit, linked to an increase in vasomotility, in such cases. Overall, it appears that mortality in patients receiving metformin who develop lactic acidosis is linked to underlying disease rather than to metformin accumulation, and that metformin can no longer be considered a toxic drug in this respect. These findings are likely to be of considerable relevance to the management of patients with type 2 (non-insulin-dependent) diabetes mellitus, especially where such patients are elderly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.