ArticleDigestive diseases and sciences1999
Bile acid concentrations, cytotoxicity, and pH of fecal water from patients with colorectal adenomas.
Article in Digestive diseases and sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- The effect of fecal bile acids on the incidence and risk-stratification of colorectal cancer: an updated systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Faecal steroid excretion in humans is affected by calcium supplementation and shows gender-specific differences.European journal of nutrition · 2009Trial
- Intestinal and fecal pH in human health.Frontiers in microbiomes · 2023Review
- Omega-3 Polyunsaturated Fatty Acids, Gut Microbiota, Microbial Metabolites, and Risk of Colorectal Adenomas.Cancers · 2022Article
- The Effect of Smoking on the Number and Type of Rectal Aberrant Crypt Foci (ACF)-First Identifiable Precursors of Colorectal Cancer (CRC).Journal of clinical medicine · 2020Article
- An Overview of Gut Microbiota and Colon Diseases with a Focus on Adenomatous Colon Polyps.International journal of molecular sciences · 2020Review
- Influence of Iron on the Gut Microbiota in Colorectal Cancer.Nutrients · 2020Review
- Intestinal Bacteria Interplay With Bile and Cholesterol Metabolism: Implications on Host Physiology.Frontiers in physiology · 2019Review
- Gallbladder Polyps Are Associated with Proximal Colon Polyps.Gastroenterology research and practice · 2019Article
- Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients.BMC cancer · 2018Article
- An analysis of dietary fiber and fecal fiber components including pH in rural Africans with colorectal cancer.Intestinal research · 2018Article
- Repression of intestinal transporters and FXR-FGF15 signaling explains bile acids dysregulation in experimental colitis-associated colon cancer.Oncotarget · 2017Article
- Fat, fibre and cancer risk in African Americans and rural Africans.Nature communications · 2015Article
- Effect of increased bile acid synthesis or fecal excretion in irritable bowel syndrome-diarrhea.The American journal of gastroenterology · 2014Article
- Diet, microbiota, and microbial metabolites in colon cancer risk in rural Africans and African Americans.The American journal of clinical nutrition · 2013Article
- Ursodeoxycholic acid attenuates colonic epithelial secretory function.The Journal of physiology · 2013Article
- Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells.Journal of cellular and molecular medicine · 2009Article
- Deoxycholate, an endogenous cytotoxin/genotoxin, induces the autophagic stress-survival pathway: implications for colon carcinogenesis.Journal of toxicology · 2009Article
- Association of familial colorectal cancer with variants in the E-cadherin (CDH1) and cyclin D1 (CCND1) genes.International journal of colorectal disease · 2008Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the multistage model of human colorectal tumorigenesis, both genetic and environmental factors play an important role. The identity of the environmental factors involved, however, still remains to be elucidated. As fecal bile acids are proposed as candidates, we compared the concentration of bile acids in fecal water from patients at different risk of developing colorectal cancer. In addition, pH of fecal water as well as its cytotoxicity to HT-29 colonic cells was determined. The high-risk group consisted of individuals diagnosed with one or more (tubulo)villous colorectal adenomas larger than 1 cm in diameter and containing moderate or severe dysplasia (N = 20). Subjects with colorectal adenomas smaller than 1 cm and showing only minor dysplasia were assigned to the medium risk group (N = 19). The control group consisted of persons with normal findings by colonoscopy (N = 25). The results show no significant differences in fecal water bile acid concentrations between the three groups. However, 46% of the observed cytotoxicity is explained in a regression model that includes pH and the concentrations of deoxycholic acid, cholic acid, and ursodeoxycholic acid. The pH of fecal water is found to be significantly lower in the high risk group as compared to the controls, suggesting that a relatively high fecal pH has a protective effect on the development of colorectal adenomas. Although hyperproliferation as a result of cytotoxicity has been suggested to contribute to tumor formation in the colon, the pH-dependent cytotoxicity of bile acids in fecal water was not found to be associated with adenoma formation in the present study.
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Registered trials
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